Results 71 to 80 of about 8,444,075 (296)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Robust Diffusion Affine Projection Algorithm With Variable Step-Size Over Distributed Networks
IEEE Access, 2019 The estimation performance of the standard diffusion affine projection algorithm may be degraded when the distributed network nodes are disturbed by impulsive noise. To overcome the limitation, a diffusion affine projection M-estimate (DAPM) algorithm is
Pucha Song, Haiquan Zhao, Xiangping Zeng
doaj +1 more source
, 2019 This letter proposes a variable step-size (VSS) affine projection algorithm (APA) associated with a step-size scaler to improve the APA's robustness against impulsive measurement noise. In the proposed VSS APA, the step-size scaler is applied to the
Park, P, Song, Insun
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
An Improved Adaptive Variable Step Size LMS Algorithm for Harmonic Detection
Kongzhi Yu Xinxi Jishu, 2017 It is difficult to detect harmonic current accurately when APF in low SNR condition. In order to improve the accuracy and tracking speed of harmonic current detection, an improved variable step-size LMS (least mean square ) algorithm was proposed based ...
ZHANG Han
doaj
Model Selection for Support Vector Machines
, 2001 The generalisation properties of a support vector classi cation network are typically governed by a regularisation parameter, #, and a small number of parameters specifying the kernel function. The process by which the optimal values of these parameters
Via Adaptive Step-Size
core
Variable Step Size Maximum Correntropy Criteria Based Adaptive Filtering Algorithm [PDF]
, 2016 Maximum correntropy criterion (MCC) based adaptive filters are found to be robust against impulsive interference. This paper proposes a novel MCC based adaptive filter with variable step size in order to obtain improved performance in terms of both ...
Radhika, S., Sivabalan, A.
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source