Results 11 to 20 of about 1,777 (106)

De Novo Design of Multivalent α/β‐Peptides Mimicking Transcription Factors Targeting the CBP KIX Domain

Chemistry – A European Journal, EarlyView.
A modular, de novo α/β‐peptide design strategy allows fine‐tuning of ligand properties, resulting in multivalent ligands that simultaneously target separate binding sites on the protein surface. ABSTRACT Protein‐protein interactions that regulate gene expression in the nucleus are increasingly recognized as potential therapeutic targets but present ...
Márk V. Tresztián, Vencel L. Petrovicz, Edit Wéber, Tamás A. Martinek, Zsófia Hegedüs   +4 more
wiley   +1 more source

Emergence of Institutional Isomorphism in the Environmental, Social, and Governance Performance of European Banks

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study investigates whether institutional isomorphism contributes to the convergence of environmental, social, and governance (ESG) performance among 230 banks in the European Union and the European Free Trade Association from 2011 to 2021.
Balázs Tóth, Tamás Attila Rácz, Dániel Szládek, Edit Lippai‐Makra   +3 more
wiley   +1 more source

CardiLect: A combined cross‐species lectin histochemistry protocol for the automated analysis of cardiac remodelling

ESC Heart Failure, Volume 12, Issue 2, Page 1398-1415, April 2025.
Abstract Background Cardiac remodelling, a crucial aspect of heart failure, is commonly investigated in preclinical models by quantifying cardiomyocyte cross‐sectional area (CSA) and microvascular density (MVD) via histological methods, such as immunohistochemistry.
Tamás G. Gergely, Tamás Kovács, Andrea Kovács, Viktória E. Tóth, Nabil V. Sayour, Gábor M. Mórotz, Csenger Kovácsházi, Gábor B. Brenner, Zsófia Onódi, Balázs Enyedi, Domokos Máthé, Przemyslaw Leszek, Zoltán Giricz, Péter Ferdinandy, Zoltán V. Varga   +14 more
wiley   +1 more source

DECREASE study: A European pool‐analysis of patients with significant reductions in concomitant antiseizure medications in cenobamate Early Access Programs

Epilepsia Open, EarlyView.
Abstract Objective To evaluate the effectiveness and tolerability of cenobamate in patients with a significant reduction in concomitant antiseizure medication (ASM) in European cenobamate Early Access Programs (EAPs). Method Anonymized patient data from real‐world studies/registries associated with European cenobamate EAPs were pooled.
Vicente Villanueva, Simona Lattanzi, Javier Peña‐Ceballos, Rhys H. Thomas, Juan Rodríguez‐Uranga, Zsófia Jordán, Bernhard J. Steinhoff, Randi von Wrede, Norman Delanty, Patrick B. Moloney, Roberta Roberti, Giovanni Boero, Laura Canafoglia, Nicola Specchio, Antonio Gambardella, Edoardo Ferlazzo, Francesca Felicia Operto, Elena Tartara, Hester Garratt, Dániel Fabó, Asier Gómez‐Ibáñez, Gustavo Torres‐Gaona, Yulia Novitskaya, Rainer Surges, Kevin Hampel, Andreas Schulze‐Bonhage   +25 more
wiley   +1 more source

Conceptual Learning in Orthodontics: A Systematic Literature Review of Its Implementation and Impact on Clinical Decision‐Making

Journal of Dental Education, EarlyView.
ABSTRACT Background Orthodontic education has traditionally relied on didactic instruction and rule‐based teaching approaches. Increasing emphasis on clinical reasoning and evidence‐based treatment planning has led to the integration of conceptual learning strategies—approaches that emphasize understanding relationships between clinical concepts and ...
Martin Baxmann, Márton Zsoldos, Krisztina Kárpáti   +2 more
wiley   +1 more source

Deep learning cone‐beam computed tomography image segmentation for the 3D visualization of mandibular infraosseous periodontal defects

Journal of Periodontology, EarlyView.
Abstract Background The accurate assessment of infraosseous periodontal defects is crucial for effective diagnosis and treatment planning. Cone‐beam computed tomography (CBCT) enables detailed imaging of these defects; however, to leverage their full potential, CBCT images must be reconstructed in 3 dimensions (3D).
Daniel Palkovics, Balint Molnar, Csaba Pinter, David García‐Mato, Andres Diaz‐Pinto, Attila Tanacs, Andrea Dobos, Peter Windisch, Christoph A. Ramseier   +8 more
wiley   +1 more source

A Simple, Dynamic Geometric Phantom for MRI and CT Reconstruction Pipelines: Beyond Shepp–Logan

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT A customizable, dynamic geometric phantom was developed to bridge the gap between simplistic static phantoms and highly realistic, complex 4D solutions. The phantom enables initial testing, helps detect implementation errors, and supports quantitative evaluation of new dynamic acquisition and reconstruction methods.
Tamás Hakkel, Noémi Kovács, József Sinkó, Domokos Máthé, Krisztián Szigeti   +4 more
wiley   +1 more source

Angle‐dependent X‐ray absorption correction in small‐ and wide‐angle X‐ray scattering: accounting for constrained scattering volume, beam profiles and capillary wall attenuation

Journal of Applied Crystallography, EarlyView.
We present an improved numerical angle‐dependent absorption correction procedure for line‐collimated small‐ and wide‐angle X‐ray scattering measurements in thin‐walled quartz capillaries. The procedure accounts for the constrained illuminated volume, measured primary beam profiles and capillary‐wall absorption, enabling physically consistent data ...
Jure Kovač, Andrej Jamnik, István Szilágyi, Matija Tomšič   +3 more
wiley   +1 more source

Living Together, Loving Apart: Health, Sexuality and Relationships in Middle‐Aged and Older Men in Europe

Andrology, EarlyView.
ABSTRACT Background Over time, family structures have grown more complex, diversifying adult relationships. While research has compared marital, cohabiting and living apart together relationships based on quality and health, less is known about their sexual dynamics.
Clotilde Sparano, Giammarco Alderotti, Giulia Rastrelli, Giovanni Corona, Leen Antonio, Felipe F. Casanueva, Aleksander Giwercman, Thang S. Han, Ilpo T. Huhtaniemi, Chiara Lucchi, Terence O'Neill, Jolanta Słowikowska‐Hilczer, Jos Tournoy, Dirk Vanderschueren, Frederick Wu, Daniele Vignoli, Mario Maggi   +16 more
wiley   +1 more source

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source