A One Health Molecular Investigation and Exploratory Epidemiological Analysis of Cryptosporidium spp. in A Shared Human-Animal Ecosystem. [PDF]
Vet Med SciWakid MH +6 more
europepmc +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Data Completeness and Acceptability of Annual Feedback Reports and Tuberculosis Surveillance in Spain, 2018-2024: Mixed Methods Analysis. [PDF]
JMIR Public Health SurveillChatterjee A +8 more
europepmc +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Classification of pre-metabolic syndrome and metabolic syndrome using machine learning and routine clinical variables in Thai adults. [PDF]
PLoS OneYaikwawong M, Kamdee K, Chuengsamarn S.
europepmc +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
College Education and Wages in the U.K.: Estimating Conditional Average Structural Functions in Nonadditive Models with Binary Endogenous Variables [PDF]
We propose and implement an estimator for identifiable features of correlated random coefficient models with binary endogenous variables and nonadditive errors in the outcome equation.
Tobias J. Klein
core
Upper-Limb Paresis Severity Is Associated With Practice Dosage During Task-Oriented Training in Subacute Stroke-An Exploratory Secondary Analysis. [PDF]
Physiother Res IntDurairaj S +3 more
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
DISCARDING VARIABLES in PRINCIPAL COMPONENT ANALYSIS : ALGORITHMS for ALL-SUBSETS COMPARISONS [PDF]
The traditional approach to the interpretation of the results from a Principal Component Analysis implicitly discards variables that are weakly correlated with the most important and/or most interesting Principal Components.
A. Pedro Duarte Silva
core