Results 31 to 40 of about 5,585,321 (191)

Redshift distribution of gamma-ray bursts and star formation rate [PDF]

open access: yes, 2006
Aims. The redshift distribution of gamma-ray bursts collected in the BATSE Catalog is compared with the star formation rate.We aim to clarify the accordance between them. We also study the case of comoving number density of bursts monotonously increasing
Bagoly, Zsolt   +19 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Determining the best population-level alcohol consumption model and its impact on estimates of alcohol-attributable harms

open access: yesPopulation Health Metrics, 2012
Background The goals of our study are to determine the most appropriate model for alcohol consumption as an exposure for burden of disease, to analyze the effect of the chosen alcohol consumption distribution on the estimation of the alcohol Population ...
Kehoe Tara   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

A Patients-Based Statistical Model of Radiotherapy Dose Distribution in Nasopharyngeal Cancer

open access: yesDose-Response, 2019
Purpose: To develop a patients-based statistical model of dose distribution among patients with nasopharyngeal cancer (NPC). Methods and Materials: The dose distributions of 75 patients with NPC were acquired and preprocessed to generate a dose-template ...
Gang Liu   +9 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Evaluating a novel reproduction number estimation method: a comparative analysis

open access: yesScientific Reports
This paper presents practical methodologies for determining effective reproduction numbers, R(t), providing valuable insights for researchers and public health officials.
Katsuro Anazawa
doaj   +1 more source

On Properties of the Hyperbolic Distribution

open access: yesMathematics
This paper is set to analytically describe properties of the hyperbolic distribution. This law, along with the variance-gamma distribution, is one of the most popular normal mean–variance mixtures from the point of view of various applications.
Roman V. Ivanov
doaj   +1 more source

A Note on Estimation for the First Order Autoregressive Process [PDF]

open access: yesThe Egyptian Statistical Journal, 1987
The asymptotic estimation of the parameters of the first order stationary autoregressive process with zero mean is investigated. The exact and the asymptotic Bayes esti- mates of the weight and the error variance parameters are derived for different ...
A.M. Abouammoh, A.A. Abd-Alla
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

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