Results 121 to 130 of about 1,198,252 (292)

Adaptive variance function estimation in heteroscedastic nonparametric regression [PDF]

, 2008
T. Tony Cai, Lie Wang
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Variance Function Partially Linear Single-Index Models^1. [PDF]

J R Stat Soc Series B Stat Methodol, 2015
Lian H, Liang H, Carroll RJ.
europepmc   +1 more source

A Stepwise Confidence Interval Procedure Under Unknown Variances Based on an Asymmetric Loss Function for Toxicological Evaluation [PDF]

, 2015
Lei Cao, Jian Tao, Ningzhong Shi, Wei Liu   +3 more
openalex   +1 more source

Optimal designs for variance function estimation using sample variances

, 1999
Using sample variances for estimating a variance function is intuitively more appealing than using residuals. Main advantage of sample variances over residuals is that they are robust to misspecification of the mean function. However, due to the replication requirement neither standard response surface designs nor small designs generated by design ...
Goos, Peter, Tack, Lieven, Vandebroek, Martina   +2 more
openaire   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Intelligent islanding detection in smart microgrids using variance autocorrelation function‐based modal current envelope

IET Smart Grid
Islanding detection is a critical issue in grid‐connected distributed microgrid systems. Distributed generation in the current power system has caused many challenges.
Shanzah Naseem, Sadiq Ahmad, Saddam Aziz, Muhammad Ali, Kazi N. Hasan, Ayaz Ahmad, Abdullah Shoukat   +6 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Semiparametric quasilikelihood and variance function estimation in measurement error models

, 1993
Jungsywan H. Sepanski, Raymond J. Carroll   +1 more
openalex   +2 more sources