Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
TOPAS simulation of photoneutrons in radiotherapy: accuracy and speed with variance reduction. [PDF]
Ramos-Mendez J +4 more
europepmc +1 more source
A Measurement-Data-Driven Control Approach towards Variance Reduction of Micromachined Resonant Accelerometer under Multi Unknown Disturbances. [PDF]
Shen Q +5 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Prediction and influence factors analysis of IP backbone network traffic based on Prophet model and variance reduction. [PDF]
Wei X.
europepmc +1 more source
Some variance reduction methods for numerical stochastic homogenization. [PDF]
Blanc X, Le Bris C, Legoll F.
europepmc +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Retraction: The value of Monte Carlo model-based variance reduction technology in the pricing of financial derivatives. [PDF]
PLOS ONE Editors.
europepmc +1 more source
Variance Reduction during the Fabrication of Sub-20 nm Si Cylindrical Nanopillars for Vertical Gate-All-Around Metal-Oxide-Semiconductor Field-Effect Transistors. [PDF]
Ye S, Yamabe K, Endoh T.
europepmc +1 more source

