Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Variance reduction and measurement errors in estimating lactation milk yields using best prediction: An analytical review. [PDF]
Wu XL, VanRaden PM, Cole J, Norman HD.
europepmc +1 more source
Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations. [PDF]
Ramos-Méndez J +5 more
europepmc +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Estimating thermodynamic expectations and free energies in expanded ensemble simulations: Systematic variance reduction through conditioning. [PDF]
Athènes M, Terrier P.
europepmc +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Bias and variance reduction in estimating the proportion of true-null hypotheses. [PDF]
Cheng Y, Gao D, Tong T.
europepmc +1 more source
Efficiency improvement and variance reduction [PDF]
openaire +1 more source
The human gut microbiome across the life course
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Variance reduction in randomised trials by inverse probability weighting using the propensity score. [PDF]
Williamson EJ, Forbes A, White IR.
europepmc +1 more source

