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Selecting Variants in Pharyngeal Reconstruction
Annals of Otology, Rhinology & Laryngology, 1984A dramatic change in the techniques of immediate pharyngeal reconstruction in the last 10 years is largely due to the availability of myocutaneous flaps, microvascular techniques, and the increasing popularity of the “gastric pull-up” operation. The experience of the Head and Neck Service of Memorial Sloan-Kettering Cancer Center in repair of the ...
J P, Shah +3 more
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Pathogens select for genomic variants
Science, 2017Malarial Genomics Large-scale deletions and duplications of genes, referred to as structural variants (SVs), are common within the human genome and have been linked to disease. Examining a genomic region that appears to confer a selective benefit, Leffler et al.
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Crystallographic variant selection in α–β brass
The transformation texture of α/β brass with a diffusional Widmanstätten α growth morphology has been investigated. Electron micrographs and electron backscattered diffraction was used to determine that the orientation relationship between the β phase ...
N Stanford
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Selecting variants in cheek reconstruction
Indian Journal of Otolaryngology and Head and Neck Surgery, 1994Total cheek defects in twenty cases of carcinoma of the buccal mucosa undergoing ablative surgery were reconstructed. A pectoralis major myocutaneous flap (alone or in combination with another flap) and cervicofacial flap were the most common methods used (ten and eight cases respectively).
D. A. Tandon, S. Bahadur
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Natural Selection at Rare Variants
2015Rare variants generally have recent origins from new mutations. Up to half of new mutations in protein-coding regions, and an unknown proportion elsewhere in the genome, have predicted deleterious consequences. Thus, purifying selection on rare variants is common and can be detected from a deficit of certain classes of variant, from functional ...
Yali Xue, Chris Tyler-Smith
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Immune Selection of Virus Variants
1984Virus infections in animals involve complex virus-host interactions in which various schemes of replication of the agent are pitted against a multitude of host-defense mechanisms. The immune system is the most effective of the antiviral host defenses and usually succeeds in eliminating pathogens after brief periods of infection.
Janice E. Clements, Opendra Narayan
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In vitro selection of Junin virus antigenic variants
Archives of Virology, 1993The establishment of an experimental persistent infection with Junin virus, the aetiological agent of argentine hemorrhagic fever, involves the emergence of antigenic variants in brain and blood of the cricetid Calomys musculinus. We demonstrate that antigenic variants can also be isolated in vitro under the selective pressure of polyclonal antibodies ...
L E, Alché, C E, Coto
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Selection Probability for Rare Variant Association Studies
Journal of Computational Biology, 2017In human genome research, genetic association studies of rare variants have been widely studied since the advent of high-throughput DNA sequencing platforms. However, detection of outcome-related rare variants still remains a statistically challenging problem because the number of observed genetic mutations is extremely rare.
Gira Lee, Hokeun Sun
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