Results 111 to 120 of about 4,852,808 (314)

Genetic analysis of environmental variation [PDF]

, 2010
Environmental variation (V-E) in a quantitative trait - variation in phenotype that cannot be explained by genetic variation or identifiable genetic differences - can be regarded as being under some degree of genetic control. Such variation may be either
HAN A. MULDER, Hill, William G., WILLIAM G. HILL, Mulder, H.A., Mulder, Han A., Hill, W.G.   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evaluating environmental DNA detection of a rare fish in turbid water using field and experimental approaches [PDF]

PeerJ
Detection sensitivity of aquatic species using environmental DNA (eDNA) generally decreases in turbid water but is poorly characterized. In this study, eDNA detection targeted delta smelt (Hypomesus transpacificus), a critically endangered estuarine fish
Ann E. Holmes, Melinda R. Baerwald, Jeff Rodzen, Brian M. Schreier, Brian Mahardja, Amanda J. Finger   +5 more
doaj   +2 more sources

Variation in Variation Measurement: A Mapping Review of Methods to Study Clinical Variation

Journal of Evaluation in Clinical Practice
ABSTRACT Rationale Variation in health care delivery exists at many levels (e.g., provider, practice, system) and can often be explained by various factors at each level. Understanding clinical variation presents an opportunity to improve the value of health care by identifying low‐value care ...
Amity E. Quinn, Jason E. Black, Derek Chew, Tyler S. Williamson, Dean Yergens, Peter Faris, Flora Au, Jane M. Fletcher, Simarprit Sidhu, Rachelle Drummond, Becky Skidmore, Braden Manns   +11 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Biological variation of laboratory analytes based on the 1999-2002 National Health and Nutrition Examination Survey [PDF]

"OBJECTIVE: Biological variation consists of within-person (WP) and between-person (BP) variation. These components of biological variation are used to set analytical goals for imprecision and bias, evaluate serial changes for individual analytes, and ...

core  

Frequency and intensity of tropical disturbances over the Indian region and its neighboring seas with associated rainfall during the monsoon season: A perspective

Engineering Reports, 2019
India, a leading developing country in the Asian continent, is worldwide famous for its diversified and complex monsoon rainfall system, and the factors associated with it.
Shobha Shivaram Nandargi, Shanti Shwarup Mahto   +1 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Adaptive individual variation in phenological responses to perceived predation levels

Nature Communications, 2019
For phenotypic plasticity to evolve to a changing world, there must be variation in plasticity. Here, the authors show that whether great tits advance or delay breeding in response to perceived predation risk depends on their personality, linking ...
Robin N. Abbey-Lee, Niels J. Dingemanse
doaj   +1 more source