Results 181 to 190 of about 9,552,128 (326)

Predictors of carotenoid status in New Zealand children using carotenoid reflection score: a cross-sectional study. [PDF]

Asia Pac J Clin Nutr
Rapson J, Rush E, McLean R, Fuavao K, Wall C, Eyles H.   +5 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Removal of unwanted variation in pseudobulk analysis of single-cell RNA sequencing data and the leveraging of pseudoreplicates. [PDF]

NAR Genom Bioinform
Prieto León S, De Troyer E, Geys H, Van den Berge K, Thas O.   +4 more
europepmc   +1 more source

Dense gas is not enough: environmental variations in the star formation efficiency of dense molecular gas at 100 pc scales in M 51 [PDF]

, 2019
M. Querejeta, E. Schinnerer, A. Schruba, Murphy E, S. Meidt, A. Usero, A.K. Leroy, J. Pety, F. Bigiel, M. Chevance, C. M. Faesi, M. Gallagher, S. Garcia-Burillo, S. C. O. Glover, A P S Hygate, M. J. Jiménez Donaire, J. M. D. Kruijssen, E. Momjian, E. Rosolowsky, D. Utomo, M. Querejeta, E. Schinnerer, A. Schruba, Murphy E, S. Meidt, A. Usero, A.K. Leroy, J. Pety, F. Bigiel, M. Chevance, C. M. Faesi, M. Gallagher, S. Garcia-Burillo, S. C. O. Glover, A P S Hygate, M. J. Jiménez Donaire, J. M. D. Kruijssen, E. Rosolowsky, D. Utomo   +38 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Temperature and plant-available soil phosphorus drive intraspecific variation in plant economic traits of Schima superba across an elevation gradient. [PDF]

Ann Bot
Li J, Westerband AC, Wright IJ, Li X, Du J, Zhong Q, Hu D, Cheng D.   +7 more
europepmc   +1 more source

Latitudinal variation in soil biota: testing the biotic interaction hypothesis with an invasive plant and a native congener [PDF]

, 2018
Xinmin Lu, Minyan He, Jianqing Ding, Evan Siemann   +3 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Pangenomics in the Mimulus guttatus Species Complex. [PDF]

Mol Ecol Resour
James ME.
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source