Results 251 to 260 of about 4,172,585 (318)

A comprehensive dataset of static and dynamic signs for the Mexican Sign Language alphabet. [PDF]

Data Brief
Lopez-Nava IH, Navarrete-López JA, Morfín-Chávez RF.   +2 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

L'antonymie: fonctions sémantico-référentielles de la co-présence d'antonymes français

, 2019
Steffens, M.G., LS Franse Taalkunde, ILS Variation   +2 more
core  

Kin Association During Nest Founding in the Bee Exoneura Bicolor: Active Discrimination, Philopatry and Familiar Landmarks

Psyche: A Journal of Entomology, 1991
Michael P. Schwarz, Mark W. Blows
doaj   +1 more source

Genes Versus Environment: Body Size Variation Among Recruitment Cohorts of Dungeness Crab. [PDF]

Mol Ecol
Dimond JL, Grossman SK, Buckner EV, Cook CE, Bosley KM, Tobin ED, Barber JS.   +6 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Illuminating hidden genetic architecture in autism. [PDF]

Cell Genom
Chahrour MH.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Three-Dimensional Variation of the Human Hard Palate Across Populations: A Geometric Morphometrics Study. [PDF]

Dent J (Basel)
Chiam TL, Gurr A, Hughes T, Palmer L, Higgins D.   +4 more
europepmc   +1 more source