Results 251 to 260 of about 4,989,187 (307)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Capturing Heterogeneous Time-Variation in Covariate Effects in Non-Proportional Hazard Regression Models. [PDF]

Biom J
Hagemann N, Kneib T, Möllenhoff K.
europepmc   +1 more source

Inter-anesthesiologist Practice Variation in Vasopressor Administration for Intraoperative Hypotension: A Retrospective Cohort Study. [PDF]

Cureus
George D, Van Rompaey N, Noel E.
europepmc   +1 more source

Analysis of Maxwell nanofluid model with convective variations, variable-density and heat generation in a porous medium. [PDF]

Discov Nano
Alrehili M.
europepmc   +1 more source