Results 281 to 290 of about 9,552,128 (326)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Divergent and stabilizing selection shape the phenotypic space of Arabidopsis thaliana. [PDF]

PLoS Biol
Przybylska MS, Violle C, Vile D, Scheepens JF, Cornet D, Beurier G, Rouan L, Estarague A, Kazakou E, Mahaut L, Munoz F, Weigel D, Exposito-Alonso M, Bossdorf O, Chevin LM, Vasseur F.   +15 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Are Large-Scale Differences in Temperature and Reindeer Management Regime Affecting the Quality of Reindeer's Summer Forage? [PDF]

Ecol Evol
Berthelot F, Stien A, Soininen EM, Tveraa T, Böhner H, Bråthen KA.   +5 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Delineation in fuzzy boundaries: Canonical ordination analysis discriminates between cryptic species by linking taxonomy to genetics, morphology, climate, and space. [PDF]

PLoS One
Sîrbu I, Benedek AM, Hofman S, Jaszczyńska A, Falniowski A.   +4 more
europepmc   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Effects of glucocerebrosidase gene variations on the risk of Parkinson's disease dementia: a meta-analysis. [PDF]

Front Aging Neurosci
Li Q, Bi Z, Liang W, Yin S, Li H, Liang Z, Wu M, Quan J, Li C.   +8 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Inequitable Variation

Journal of the Royal College of Physicians of London, 1996
openaire   +2 more sources