Results 291 to 300 of about 7,252,224 (344)

Effects of rhythmic auditory stimulation prior to walking on step time and trunk acceleration during the first five steps of walking initiation: a preliminary study in healthy adults. [PDF]

J Phys Ther Sci
Takahashi Y, Iwatsuki H, Kado N, Maeda T, Kurobe M, Suzuki T.   +5 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The impact of dynamic reversal potential on the evolution of action potential attributes during spike trains. [PDF]

Front Comput Neurosci
Aldohbeyb AA, Vigh J, Lear KL.
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

ACMTF-R: Supervised multi-omics data integration uncovering shared and distinct outcome-associated variation. [PDF]

PLoS One
van der Ploeg GR, White FTG, Jakobsen RR, Westerhuis JA, Heintz-Buschart A, Smilde AK.   +5 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Comparison of real-time quantitative PCR and two digital PCR platforms to detect copy number variation in FCGR3B

Kirstine Kløve‐Mogensen, Simone Karlsson Terp, Rudi Steffensen   +2 more
openalex   +1 more source

Two temperatures effect on wave propagation in microstretch thermoelastic medium with microtemperatures. [PDF]

Sci Rep
Kaur M, Kumar R, Sharma S, Taha HH, Kamel A, El-Bary AA, Lotfy K.   +6 more
europepmc   +1 more source

Fructose-sweetened beverages induce diurnal redox dysregulation in pediatric MASLD. [PDF]

Redox Biol
Huneault HE, Gillespie SE, Jarrell ZR, Bai S, Tovar AR, Sanchez-Torres C, Gonzalez-Ramirez LA, Chatman KC, Ziegler TR, Jones DP, Welsh JA, Vos MB.   +11 more
europepmc   +1 more source

Everything is everywhere but Escherichia coli adapts to different niches. [PDF]

ISME J
Monteith W, Krisna MA, Garcias B, Cummins EA, Kelly DJ, Taylor AJ, Sheppard SK.   +6 more
europepmc   +1 more source