Results 71 to 80 of about 3,271,603 (299)

Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma

Frontiers in Genetics, 2013
Increasing evidence suggests that single nucleotide polymorphisms (SNPs) associated with complex traits are more likely to be expression quantitative trait loci (eQTLs).
Lin eLi, Michael eKabesch, Emmanuelle eBouzigon, Emmanuelle eBouzigon, Florence eDemenais, Florence eDemenais, Martin eFarrall, Miriam F. Moffatt, Xihong eLin, Liming eLiang, Liming eLiang   +10 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Decision Algorithm for the Automatic Determination of the Use of Non-Inclusive Terms in Academic Texts

Publications, 2020
The use of inclusive language, among many other gender equality initiatives in society, has garnered great attention in recent years. Gender equality offices in universities and public administration cannot cope with the task of manually checking the use
Pedro Orgeira-Crespo, Carla Míguez-Álvarez, Miguel Cuevas-Alonso, María Isabel Doval-Ruiz   +3 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Decadal Regime Shifts in Sea Fog Frequency over the Northwestern Pacific: The Influence of the Pacific Decadal Oscillation and Sea Surface Temperature Warming

Atmosphere
Sea fog significantly impacts marine activities, ecosystems, and radiation balance. We analyzed the decadal variation characteristics of sea fog frequency (SFF) over the northwestern Pacific and investigated the roles of the Pacific decadal oscillation ...
Shihan Zhang, Liguo Han, Jingchao Long, Lingyu Dong, Pengzhi Hong, Feng Xu   +5 more
doaj   +1 more source

On a variational problem

Journal of Mathematical Analysis and Applications, 1974
Some examples and technical assumptions will appear in Section 2. We are looking in this paper for conditions on u and g which will imply that for every a there exists a measurable solution x(t) to the problem B(u, g, a). A somewhat weaker version of this problem, namely when X is the nonnegative orthant of the n-dimensional space and g(x, t) = x, was ...
openaire   +2 more sources

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

The Impacts of Regime Shift in Summer Arctic Oscillation on Precipitation in East Asia

Atmosphere
Using multiple observational and reanalysis data, this paper investigates the impact of the interdecadal shift in summer Arctic Oscillation (AO) on precipitation in East Asia, by removing ENSO influences.
Xuxin Zou, Li Yan, Jianjun Xu, Shaojun Zheng   +3 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source