Results 91 to 100 of about 558,212 (268)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Regional variation in use of immediate breast reconstruction after mastectomy for breast cancer in England.

, 2010
AIMS: English national guidelines recommend that breast reconstruction is made available to women with breast cancer undergoing mastectomy. We examined the use of immediate reconstruction (IR) across English Cancer Networks, who are responsible for the ...
van der Meulen, JHP, van der Meulen, Jan H.P., Pereira, Jerome, Cromwell, DA, Trivella, M, Cromwell, David A., Pereira, J., Sheppard, C., Jeevan, R., Trivella, Maria-Heleni, Caddy, C.M., Browne, John P., R. Jeevan, Caddy, CM, Caddy, Ranjeet, Browne, J.P., Jeevan, R, Van Der Meulen, J.H.P., Sheppard, C, Browne, JP, Cromwell, D.A., Sheppard, Chris M., C. Sheppard, D.A. Cromwell, J.P. Browne, Trivella, M., J.H.P. van der Meulen, Pereira, J, M. Trivella, C.M. Caddy, Jeevan, Ranjeet, J. Pereira   +31 more
core   +1 more source

Anticipated climate and land-cover changes reveal refuge areas for Borneo's orang-utans [PDF]

, 2015
Habitat loss and climate change pose a double jeopardy for many threatened taxa, making the identification of optimal habitat for the future a conservation priority.
Fischer, M., Catherine Gonner, Gaveau, David L A, Wich, Serge A., Erik Meijaard, Wilting, A., Sykes, Rachel, Kramer-Schadt, Stephanie, Kramer-Schadt, S., Rachel Sykes, Manuela Fischer, Struebig, Matthew J, Gonner, C., Gonner, Catherine, Wich, Serge A, Skyes, R., Meijaard, E., Gaveau, D.L.A., Meijaard, Erik, Sykes, Rachel E., Struebig, Matthew J., David L. A. Gaveau, Gaveau, David L. A., Struebig, M., Matthew J. Struebig, Fischer, Manuela, Serge A. Wich, Wich, S., Andreas Wilting, Wilting, Andreas, Stephanie Kramer‐Schadt   +30 more
core   +1 more source

Trends in stroke mortality among older adults (≥65 years) with chronic kidney disease in the U.S. from 1999 to 2020

Archives of Gerontology and Geriatrics Plus
Background: The U.S. population is aging alongside rising rates of chronic kidney disease (CKD). However, trends in stroke-related mortality among adults with CKD, particularly those aged >65 years, remain under-explored nationally. Objectives: To assess
Muhammad Hasnain Azeem, Danish Hassan, Sahar Imtiaz, Abdullah Shahbaz, Inamullah Soomro, Syed Rayyan Ahmed, Sukoon Mehdi Raza, Safiullah Soomro, Sheikh Abdul Qadir Jillani   +8 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Mammography screening: views from women and primary care physicians in Crete [PDF]

, 2008
Background: Breast cancer is the most commonly diagnosed cancer among women and a leading cause of death from cancer in women in Europe. Although breast cancer incidence is on the rise worldwide, breast cancer mortality over the past 25 years has been ...
Frances Griffiths, Christos Lionis, Tsiftsis Dimitris, Dimitris Tsiftsis, Trigoni, Maria, Tsiftsis, Dimitris, Koumantakis Eugenios, Maria Trigoni, Griffiths Frances, Lionis Christos, Eileen Green, Eugenios Koumantakis, Trigoni Maria, Koumantakis, Eugenios, Green Eileen, Griffiths, Frances, Lionis, Christos, Green, Eileen   +17 more
core   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Socio-economic and environmental differentials, and mortality in a developing urban area (Belo Horizonte - Brazil) [PDF]

Studies on health inequalities on developing cities are scarce. They have mainly focused on infant and child mortality and life expectancy at birth. Studies of adult mortality and cause- specific studies have seldom been
de Sousa, Romulo Paes
core   +1 more source

Epidemiology of Liver Cancer in Europe

Canadian Journal of Gastroenterology, 2000
Liver cancer (LC) ranks fifth in frequency in the world, with an estimated 437,000 new cases in 1990. The estimates are different when LC frequency is analyzed by sex and geographical areas.
F Xavier Bosch, Josepa Ribes
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source