Results 121 to 130 of about 52,593 (299)

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

open access: yesFEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Variational Methods and Critical Point Theory 2013

open access: yesAbstract and Applied Analysis, 2013
M. Victoria Otero-Espinar   +3 more
doaj   +1 more source

Multiple solutions for perturbed non-local fractional Laplacian equations

open access: yesElectronic Journal of Differential Equations, 2013
In article we consider problems modeled by the non-local fractional Laplacian equation $$\displaylines{ (-\Delta)^s u=\lambda f(x,u)+\mu g(x,u) \quad\text{in } \Omega\cr u=0 \quad\text{in } \mathbb{R}^n\setminus \Omega, }$$ where $s\in (0,1)$ is ...
Massimiliano Ferrara   +2 more
doaj  

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

open access: yesFEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso   +4 more
wiley   +1 more source

A discontinuous problem involving the p-Laplacian operator and critical exponent in $mathbb{R}^N$

open access: yesElectronic Journal of Differential Equations, 2003
Using convex analysis, we establish the existence of at least two nonnegative solutions for the quasilinear problem $$ -Delta_{p}u=H(u-a)u^{p^*-1} +lambda h(x)quadhbox{in }mathbb{R}^N $$ where $Delta_{p}u$ is the $p$-Laplacian operator, $H$ is the ...
Claudianor Oliveira Alves   +1 more
doaj  

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

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