Results 111 to 120 of about 57,276 (313)

The Variational Origin of Motion by Gaussian Curvature

, 2007
A variational formulation of an image analysis problem has the nice feature that it is often easier to predict the effect of minimizing a certain energy functional than to interpret the corresponding Euler-Lagrange equations.
Solem, Jan Erik, Overgaard, Niels,, Overgaard, Niels, Overgaard, Niels Christian, Solem, Jan Erik,   +4 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Multilevel Monte Carlo methods for ensemble variational data assimilation [PDF]

Nonlinear Processes in Geophysics
Ensemble variational data assimilation relies on ensembles of forecasts to estimate the background error covariance matrix B. The ensemble can be provided by an ensemble of data assimilations (EDA), which runs independent perturbed data assimilation and ...
M. Destouches, M. Destouches, M. Destouches, P. Mycek, P. Mycek, S. Gürol, S. Gürol, A. T. Weaver, A. T. Weaver, S. Gratton, E. Simon   +10 more
doaj   +1 more source

Continuous and discrete Clebsch variational principles [PDF]

, 2009
18.02.14 Kb.
Cotter, CJ, Holm, DD
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

On a class of semilinear elliptic problems near critical growth

International Journal of Mathematics and Mathematical Sciences, 1998
We use Minimax Methods and explore compact embedddings in the context of Orlicz and Orlicz-Sobolev spaces to get existence of weak solutions on a class of semilinear elliptic equations with nonlinearities near critical growth. We consider both biharmonic
J. V. Goncalves, S. Meira
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Variational inequations and approximation

, 1974
The existence and uniqueness of the solution of a variational inequality is considered, and methods of approximation of the solution are given.
Noor, MA
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Optimal Stopping with Dynamic Variational Preferences [PDF]

We consider optimal stopping problems in uncertain environments for an agent assessing utility by virtue of dynamic variational preferences or, equivalently, assessing risk by dynamic convex risk measures.
Daniel Engelage
core