Results 121 to 130 of about 287,859 (234)

Existence of standing waves for Schrodinger equations involving the fractional Laplacian

open access: yesElectronic Journal of Differential Equations, 2017
We study a class of fractional Schrodinger equations of the form $$ \varepsilon^{2\alpha}(-\Delta)^\alpha u+ V(x)u = f(x,u) \quad\text{in } \mathbb{R}^N, $$ where $\varepsilon$ is a positive parameter, $0 < \alpha < 1$, $2\alpha < N$, $(-\Delta ...
Everaldo S. de Medeiros   +2 more
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Multiple solutions for perturbed non-local fractional Laplacian equations

open access: yesElectronic Journal of Differential Equations, 2013
In article we consider problems modeled by the non-local fractional Laplacian equation $$\displaylines{ (-\Delta)^s u=\lambda f(x,u)+\mu g(x,u) \quad\text{in } \Omega\cr u=0 \quad\text{in } \mathbb{R}^n\setminus \Omega, }$$ where $s\in (0,1)$ is ...
Massimiliano Ferrara   +2 more
doaj  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Mixed effect estimation in deep compartment models: Variational methods outperform first-order approximations. [PDF]

open access: yesJ Pharmacokinet Pharmacodyn
Janssen A   +4 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

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