Results 121 to 130 of about 12,052,174 (276)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
On Two Iterative Methods for Mixed Monotone Variational Inequalities
Fixed Point Theory and Applications, 2010 A mixed monotone variational inequality (MMVI) problem in a Hilbert space is formulated to find a point such that for all , where is a monotone operator and is a proper, convex, and lower semicontinuous function on . Iterative algorithms are
Xu Hong-Kun, Lu Xiwen, Yin Ximing
doaj
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Multiple solutions for possibly degenerate equations in divergence form
Electronic Journal of Differential Equations, 2016 Via variational methods, we establish the existence of at least two distinct weak solutions for the Dirichlet problem associated to a possibly degenerate equation in divergence form.
Andrea Pinamonti
doaj
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Nontrivial solutions for noncooperative elliptic systems at resonance
Electronic Journal of Differential Equations, 2001 In this article we establish the existence of a nonzero solution for variational noncooperative elliptic systems under Dirichlet boundary conditions and a resonant condition at infinity.
Elves A. B. Silva
doaj
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Existence and nonexistence of nontrivial solutions for Choquard type equations
Electronic Journal of Differential Equations, 2016 In this article, we consider the nonlocal problem $$ -\Delta u+u=q(x)\Big(\int_{\mathbb{R}^N}\frac{q(y)|u(y)|^p}{|x-y|^{N-\alpha}}dy \Big)|u|^{p-2}u,\quad x\in \mathbb{R}^N, $$ where $N\geq 3$, $\alpha\in (0,N)$, $\frac{N+\alpha}{N}
Tao Wang
doaj
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source