Results 71 to 80 of about 21,388 (184)

Reinforcement Learning for Jump‐Diffusions, With Financial Applications

open access: yesMathematical Finance, EarlyView.
ABSTRACT We study continuous‐time reinforcement learning (RL) for stochastic control in which system dynamics are governed by jump‐diffusion processes. We formulate an entropy‐regularized exploratory control problem with stochastic policies to capture the exploration–exploitation balance essential for RL.
Xuefeng Gao, Lingfei Li, Xun Yu Zhou
wiley   +1 more source

Random Carbon Tax Policy and Investment Into Emission Abatement Technologies

open access: yesMathematical Finance, EarlyView.
ABSTRACT We analyze the problem of a profit‐maximizing electricity producer, subject to carbon taxes, who decides on investments into CO2$\rm CO_2$ abatement technologies. We assume that the carbon tax policy is random and that the investment in the abatement technology is divisible, irreversible, and subject to transaction costs.
Katia Colaneri   +2 more
wiley   +1 more source

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti   +2 more
wiley   +1 more source

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni   +2 more
wiley   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder   +4 more
wiley   +1 more source

Utility of local capillary supply indices: Insights from computational image‐based modelling

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Local capillary distribution and fibre geometry influence oxygen availability in skeletal muscle. Image‐based modelling of tissue PO2${{P}_{{{{\mathrm{O}}}_2}}}$ shows that area‐based measures of capillary supply – the local capillary density (LCDi) and local maximum diffusion distance (Dmax,i) – most accurately represent the ...
Abdullah A. Al‐Shammari   +6 more
wiley   +1 more source

Existence of Full Replica Symmetry Breaking for the Sherrington–Kirkpatrick Model at Low Temperature

open access: yesCommunications on Pure and Applied Mathematics, Volume 79, Issue 7, Page 1746-1770, July 2026.
ABSTRACT We verify the existence of full replica symmetry breaking (FRSB) for the Sherrington–Kirkpatrick (SK) model and determine the structure of its Parisi measure slightly beyond the high temperature regime. More specifically, we prove that the support of the Parisi measure for the SK model consists of an interval starting at the origin slightly ...
Yuxin Zhou
wiley   +1 more source

Monitoring and control of a continuous, integrated filtration‐drying system with in‐line mass spectrometry via PharmaPy

open access: yesAIChE Journal, Volume 72, Issue 6, June 2026.
Abstract This article demonstrates the integration of in‐line mass spectrometry as a process analytical technology (PAT) tool with model‐based soft sensors in a continuous filtration‐drying carousel system for solid–liquid separation (SLS) of crystal slurries.
Inyoung Hur   +3 more
wiley   +1 more source

Building a Digital Twin for Material Testing: Model Reduction and Data Assimilation

open access: yesProceedings in Applied Mathematics and Mechanics, Volume 26, Issue 2, June 2026.
ABSTRACT The rapid advancement of industrial technologies, data collection, and handling methods has paved the way for the widespread adoption of digital twins (DTs) in engineering, enabling seamless integration between physical systems and their virtual counterparts.
Rubén Aylwin   +5 more
wiley   +1 more source

Two Scale FE‐FFT‐Based Modeling of Cancellous Bone

open access: yesProceedings in Applied Mathematics and Mechanics, Volume 26, Issue 2, June 2026.
ABSTRACT Osteoporosis is characterized by a loss of volume percentage of cortical bone, which reduces the loading capacity of this organ and increases its likelihood for fractures. The disease has the highest prevalence of any bone disease worldwide, with a particularly high incidence among the elderly.
Mischa Blaszczyk   +3 more
wiley   +1 more source

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