Results 51 to 60 of about 11,355 (304)
Variational Principle in Hydrodynamics [PDF]
Progress of Theoretical Physics, 1953 A canonical formalism in hydrodynamics -is developed by aid of Clebsch's transformation. If we consider the adiabatic process where the entropy is conserved, vortex motion is found to be closely connected with the entropy. Euler's hydrodynamical equation emerges fllctorised into four fundamental equations which are discussed from the thermodynamical ...
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Two Novel Vlasov Models for Bending Analysis of Finite-Length Beams Embedded in Elastic Foundations
Buildings, 2022 The issue of soil–structure interaction (SSI) is essentially to analyze the influence of complex media on the mechanical behavior of supported structures.
Feng Yue +3 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
, 2012 This chapter describes smooth variational principles (of Ekeland type) as infinite two-player games. These variational principles are based on a simple but careful recursive choice of points where certain functions that change during the process have ...
Tiˇser Jaroslav +2 more
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Hamilton-Pontryagin Integrators on Lie Groups [PDF]
, 2007 In this thesis structure-preserving time integrators for mechanical systems whose configuration space is a Lie group are derived from a Hamilton-Pontryagin (HP) variational principle.
Bou-Rabee, Nawaf Mohammed
core +1 more source
On Ekeland’s variational principle [PDF]
Journal of Fixed Point Theory and Applications, 2011 For proper lower semi-continuous functionals bounded below which do not increase upon polarization, an improved version of Ekeland's variational principle can be formulated in Banach spaces, which provides almost symmetric points.
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source