Results 61 to 70 of about 2,013,078 (286)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A Systematic Approach to Standard Dissipative Continua
Axioms, 2023 Many isothermal dissipative continuum problems can be formulated in a variational setting using the concept of “standard dissipative continua”. A major advantage of this approach is that complex problems can be cast into a compact, thermodynamically ...
Sebastian Stark
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Action-Driven flows for causal variational principles
Forum of Mathematics, SigmaWe introduce action-driven flows for causal variational principles, being a class of nonconvex variational problems emanating from applications in fundamental physics.
Felix Finster, Franz Gmeineder
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Variational characterizations for eigenfunctions of analytic self-adjoint operator functions [PDF]
Opuscula Mathematica, 2013 In this paper we consider Rellich's diagonalization theorem for analytic self-adjoint operator functions and investigate variational principles for their eigenfunctions and interlacing statements.
Georgios Katsouleas, John Maroulas
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A Variational Principle for Ground Spaces [PDF]
Reports on Mathematical Physics, 2018 The ground spaces of a vector space of hermitian matrices, partially ordered by inclusion, form a lattice constructible from top to bottom in terms of intersections of maximal ground spaces. In this paper we characterize the lattice elements and the maximal lattice elements within the set of all subspaces using constraints on operator cones.
openaire +4 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Analyzing Sample Size in Information-Theoretic Models
MathematicsIn this paper, we delve into the complexities of information-theoretic models, specifically focusing on how we can model sample size and how it affects our previous findings.
D. Bernal-Casas, J. M. Oller
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Variational Information Principles to Unveil Physical Laws
MathematicsThis article demonstrates that the application of the variation method to purely information-theoretic models can lead to the discovery of fundamental equations in physics, such as Schrödinger’s equation.
D. Bernal-Casas, J. M. Oller
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