Results 51 to 60 of about 23,335 (263)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Approximate Dilogarithm Representation of One Variational Boundary Value Problem Solution for Circle under the Neumann Boundary Condition

Наука и техника, 2021
It is known that boundary value problems for the Laplace  and Poisson equations are equivalent to the problem of the calculus of variations  – the minimum of an integral for which the given partial differential equation is the Euler – Lagrange equation.  
I. N. Meleshko, P. G. Lasy
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

БАГАТОКРИТЕРІАЛЬНА ОПТИМІЗАЦІЯ ДИНАМІЧНИХ СИСТЕМ УПРАВЛІННЯ

Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2014
У статті розглядаються динамічні системи управління. В таких системах критерій якості управління являє собою функціонал, визначений на її рішеннях. Екстремізація функціоналів є предметом варіаційного обчислення.
Albert M. Voronin, Yurii K. Ziatdinov, Oleksandr Y. Permiakov, Ihor D. Varlamov   +3 more
doaj  

ON OPTIMAL 2-D DOMAIN SEGMENTATION PROBLEM VIA PIECEWISE SMOOTH APPROXIMATION OF A SELECTIVE TARGET MAPPING

Journal of Optimization, Differential Equations and Their Applications, 2019
In this paper we propose a new technique for the solution of the image segmentation problem which is based on the concept of a piecewise smooth approximation of some target functional.
Volodymyr V. Hnatushenko, Peter I. Kogut, Mykola V. Uvarov   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

On Multiobjective Duality For Variational Problems [PDF]

The Open Operational Research Journal, 2012
Summary: Two types of duals are considered for a class of variational problems involving higher order derivatives. The duality results are derived without any use of optimality conditions. One set of results is based on Mond-Weir type dual that has the same objective functional as the primal problem but different constraints.
Husain, I., Ahmad, Bilal, Jabeen, Z.
openaire   +2 more sources