Results 111 to 120 of about 2,990,644 (312)
Variation in Variation Measurement: A Mapping Review of Methods to Study Clinical Variation
Journal of Evaluation in Clinical PracticeABSTRACT Rationale Variation in health care delivery exists at many levels (e.g., provider, practice, system) and can often be explained by various factors at each level. Understanding clinical variation presents an opportunity to improve the value of health care by identifying low‐value care ...
Amity E. Quinn +11 more
openaire +2 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
PERONEUS TERTIUS: VARIATIONS AND CLINICAL APPLICATIONS IN GUJARATI POPULATION
National Journal of Medical Research, 2021 Introduction: Peroneus tertius (PT) is a muscle of the anterior compartment of the leg. The PT muscle originates from the anterior surface of the fibula and the interosseous membrane and inserts into the medial side of the dorsal region of the fifth ...
Rashvaita K Patel, Vipul D Patel
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Small area variations and welfare loss in the use of antibiotics in the community [PDF]
This paper seeks to explain local variations in the use of antibiotics in the community and to assess the welfare loss due to heterogeneous attitudes towards the risk of bacterial infections and resistance. Significant differences are observed in the per
Karine Moschetti +2 more
core +1 more source
Calculus of variations: A differential form approach
We study integrals of the form integral(Omega) f(d omega(1), ..., d omega(m)), where m >= 1 is a given integer, 1 R is a continuous function. We introduce the appropriate notions of convexity, namely vectorial ext.
Sil, Swarnendu
core +1 more source
Crisis, anarchia, democratia [PDF]
, 2012 Variations – revue internationale de théorie critique - mérite apparemment bien son nom, puisque ses lecteurs se situent désormais dans pas moins de 35 pays de la planète.
Sagradini, Lucia +2 more
core
Les frontières de la politique
, 2012 Cette nouvelle livraison de Variations s’offre aux lecteurs alors que les frontières de la politique ont été malmenées et dérangées par les principaux candidats à la présidentielle, et qu’un homme a pu prendre le pouvoir grâce à un discours de rejet ...
Bordier, Julien +13 more
core +1 more source