Results 161 to 170 of about 2,990,644 (312)

A Decision Support Tool for the Valuation of Variations on Civil Engineering Projects [PDF]

open access: yes, 2005
The valuation of variations has been recognised as a prime cause of conflict and dispute in construction management. Such disputes often concern the prices and/or rates to be applied to the varied works.
Buckley, Kevan   +3 more
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

A recording and performer's analysis of Partita-variations for piano solo by George Rochberg

open access: yes, 2012
The purpose of this document is to provide a recording and a performer’s analysis of the piano work titled Partita-Variations by American composer George Rochberg, as well as to provide an accessible guide for the pianist in understanding his role as a ...
Chin, Yu-Ching
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Donald Grantham's Fantasy variations

open access: yes, 2003
textDonald Grantham’s composition, Fantasy Variations, started its life as a work for two pianos, commissioned by the Race/Groves Duo. The primary motivic material is based on George Gershwin’s Second Prelude from his Piano Preludes, Book 1.
Williams, Kraig Alan
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Variations on Purple Jacarandas

open access: yes, 2018
Background: Variations on Purple Jacarandas is an electroacoustic work commissioned by the Queensland Gallery of Modern Art for the Asia Pacific Triennial 9, as a sound installation to accompany the visual installation "Purple Reign", by UNSW artist Gary
Dirie, Gerardo
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Consistent conjectural variations equilibria in strategic multilateral exchange [PDF]

open access: yes
In this note, we address the problem of determining which conjectural variations general equilibria are consistent in strategic multilateral exchange. We therefore consider expectations in a simple conjectural general equilibrium model of a pure exchange
Ludovic JULIEN
core  

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