Results 141 to 150 of about 125,343 (247)
Antibiotic Stewardship in Cirrhosis: Current Recommendations and Clinical Challenges
United European Gastroenterology Journal, Volume 14, Issue 8, October 2026.ABSTRACT Bacterial infections are a major cause of mortality in cirrhosis, with antibiotic prophylaxis and empirical treatment embedded in international guidelines. However, the prevalence of multidrug‐resistant organisms and the epidemiology of infections have shifted considerably in recent decades.
Solaiman Ezzafzafi +7 more
wiley +1 more source
Alimentary Pharmacology &Therapeutics, Volume 64, Issue 8, Page 1083-1096, October 2026.In the POISE open‐label extension, patients with primary biliary cholangitis with inadequate response or intolerance to ursodeoxycholic acid received long‐term obeticholic acid (OCA) treatment. Findings demonstrated a safety profile consistent with the known characteristics of OCA, with no unexpected safety signals, while supporting sustained efficacy ...
Christopher L. Bowlus +8 more
wiley +1 more source
Alimentary Pharmacology &Therapeutics, Volume 64, Issue 7, Page 897-918, October 2026.Individualized assessment identifies patients with decompensated autoimmune hepatitis cirrhosis who are likely to benefit from a time‐limited trial of immunosuppression versus those requiring immediate liver transplant evaluation. Early objective response monitoring (bilirubin, MELD‐Na and AST/ALT) guides continuation of immunosuppression, promotes ...
Pedro Robson Costa Passos +2 more
wiley +1 more source
Hepatology Research, Volume 56, Issue 10, Page 1524-1534, October 2026.We conducted a multicenter cohort study analyzed 454 Japanese PBC patients. Baseline LSM ≥ 8.0 kPa was independently associated with adverse outcomes. ΔLSM/year ≥ 2.1 kPa was independently associated with adverse outcomes. ABSTRACT Background & Aims Liver stiffness measurement (LSM) using vibration‐controlled transient elastography (VCTE) is a ...
Yuki Yamashita +17 more
wiley +1 more source
Liver cirrhosis is associated with altered glucocorticoid metabolism related to disease severity
Journal of Internal Medicine, Volume 300, Issue 4, Page 513-527, October 2026.Abstract Background Liver cirrhosis (LC) is frequently complicated by adrenal dysfunction; however, whether cirrhosis drives the coordinated, pathway‐specific reprogramming of cortisol metabolism remains unclear. Objectives We aimed to characterize axis‐specific alterations in cortisol metabolism in patients with LC, those with adrenal insufficiency ...
Soyeon Park +8 more
wiley +1 more source
Liver International, Volume 46, Issue 10, October 2026.ABSTRACT Background & Aim Sustained‐virological‐response (SVR) after direct‐acting‐antiviral (DAA) therapy improves outcomes in patients with HCV‐related compensated‐advanced‐chronic‐liver‐disease (cACLD). However, it remains unclear whether absolute post‐SVR LSM or LSM reduction better predicts prognosis after SVR.
Federica Cerini +6 more
wiley +1 more source
Liver International, Volume 46, Issue 10, October 2026.ABSTRACT Background and Aims Assessing liver congestion and portal hypertension (PHT) in Budd–Chiari syndrome (BCS) remains challenging. We evaluated liver and spleen stiffness measurements (LSM, SSM) obtained by transient elastography as non‐invasive tools for identifying clinically meaningful liver congestion in BCS.
Andreea Fodor +22 more
wiley +1 more source
Management of varices and variceal hemorrhage in cirrhosis
Variceal hemorrhage is a lethal complication of cirrhosis, particularly in patients in whom clinical decompensation (i.e., ascites, encephalopathy, a previous episode of hemorrhage, or jaundice) has already developed.
Garcia Tsao, Guadalupe +1 more
core
Report of the CDC Working Group on Pulmonary Hemorrhage/Hemosiderosis [PDF]
hemorrhage_report ...
core
An Automated Microfluidic System for Haemostasis Assessment in Cirrhosis With Thrombocytopenia
Liver International, Volume 46, Issue 10, October 2026.ABSTRACT Background & Aims Conventional laboratory tests do not capture platelet–vessel wall interactions (primary haemostasis) occurring in vivo, limiting guidance before invasive procedures. This is relevant in patients with thrombocytopenia, hallmark of advanced cirrhosis. Microfluidic assays may overcome these limitations.
Niccolò Bitto +14 more
wiley +1 more source