Results 111 to 120 of about 68,884 (253)

Advances in the treatment of systemic lupus erythematosus: Biologicals, small‐molecular agents, and cell‐depleting therapies coming to the clinic

open access: yesJournal of Internal Medicine, Volume 300, Issue 4, Page 461-479, October 2026.
Abstract Systemic lupus erythematosus (SLE; lupus) remains a particular challenge for the practicing clinician on account of its chronic undulating and unpredictable course, its diverse manifestations, and—until recently—limited treatment options all associated with considerable downsides.
Ronald van Vollenhoven
wiley   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

open access: yesChemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier   +7 more
wiley   +1 more source

The Changing Epidemiology of Varicella Incidence after Implementation of the One-dose Varicella Vaccination Policy

open access: yes, 2012
[[abstract]]The varicella vaccine has been available in the Taiwan market since July 1997. Beginning 1998–1999, Taipei City and Taichung City/County as the early launch areas included the varicella vaccine in their free pediatric vaccination programs. By
Lian, Ie-Bin; Chien, Yu-Zen; Hsu, Pi-Shan; Chao, Day-Yu
core  

Varicella-Zoster virus seroprevalence in healthcare workers in Kuala Lumpur, Malaysia [PDF]

open access: yes, 2008
Varicella-zoster virus (VZV) infections are a particular problem in healthcare settings. A survey of chickenpox was carried out amongst healthcare workers (HCWs) following potential ward exposures. A prior history of chickenpox was given by 61/98 (62.2).
Sam, I.C.   +5 more
core   +1 more source

Cross‐tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD), but its contribution to disease pathogenesis remains incompletely understood. METHODS Here, we integrate proteomic profiling of plasma (n = 9028), cerebrospinal fluid (n = 1099), dorsolateral prefrontal cortex (n = 720), and ...
Artur Shvetcov   +19 more
wiley   +1 more source

Varicella-zoster virus infections – antiviral therapy and diagnosis

open access: yes, 2016
Varicella-zoster virus is an important human pathogen that causes varicella after primary infection and zoster after recurrence. Following primary infection, the virus remains latently for life in dorsal root and cranial nerve ganglia.
Sauerbrei, A, Sauerbrei, Andreas
core   +1 more source

Dermatome‐Specific Herpes Zoster Following Corticosteroid Therapy for Lumbar Disc Herniation: A Case Report Illustrating the Immunocompromised District Theory

open access: yesClinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Systemic corticosteroids frequently utilized to manage lumbosacral radiculopathy introduce an immunological paradox by potentially triggering varicella‐zoster virus reactivation. While well‐documented in severely immunocompromised populations, the specific neuro‐immunological mechanisms in otherwise immunocompetent patients with lumbar disc ...
Jun Liu   +11 more
wiley   +1 more source

Mycobacterium avium Complex Pulmonary Disease as a Clinical Signal of Host Vulnerability in Advanced Myelofibrosis

open access: yesClinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT An 82‐year‐old woman with JAK2‐mutated myelofibrosis who developed hemoptysis after initiation of ruxolitinib. She presented with anemia and ground‐glass opacities and was treated with antibiotics. She was readmitted with worsening respiratory symptoms. Sputum cultures yielded Mycobacterium avium.
Mataichi Sekiya   +3 more
wiley   +1 more source

Programmi di vaccinazione anti-varicella negli USA

open access: yes, 2002
Gli autori descrivono i principali risultati, ottenuti negli Stati Uniti, a seguito dell’avvio dei programmi di vaccinazione anti-varicella nell’infanzia.
VALLE S., D'ALESSANDRO, Daniela
core  

Hemorrhagic varicella

open access: yes, 2017
Varicella is a benign disorder occurring commonly in children. Hemorrhagic varicella is a serious complication occurring in immunocompromised persons or those on immunosuppressive therapy.
Bala Kumar Dorai   +4 more
core   +1 more source

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