Results 111 to 120 of about 68,884 (253)
Abstract Systemic lupus erythematosus (SLE; lupus) remains a particular challenge for the practicing clinician on account of its chronic undulating and unpredictable course, its diverse manifestations, and—until recently—limited treatment options all associated with considerable downsides.
Ronald van Vollenhoven
wiley +1 more source
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier +7 more
wiley +1 more source
[[abstract]]The varicella vaccine has been available in the Taiwan market since July 1997. Beginning 1998–1999, Taipei City and Taichung City/County as the early launch areas included the varicella vaccine in their free pediatric vaccination programs. By
Lian, Ie-Bin; Chien, Yu-Zen; Hsu, Pi-Shan; Chao, Day-Yu
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Varicella-Zoster virus seroprevalence in healthcare workers in Kuala Lumpur, Malaysia [PDF]
Varicella-zoster virus (VZV) infections are a particular problem in healthcare settings. A survey of chickenpox was carried out amongst healthcare workers (HCWs) following potential ward exposures. A prior history of chickenpox was given by 61/98 (62.2).
Sam, I.C. +5 more
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Cross‐tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease
Abstract INTRODUCTION Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD), but its contribution to disease pathogenesis remains incompletely understood. METHODS Here, we integrate proteomic profiling of plasma (n = 9028), cerebrospinal fluid (n = 1099), dorsolateral prefrontal cortex (n = 720), and ...
Artur Shvetcov +19 more
wiley +1 more source
Varicella-zoster virus infections – antiviral therapy and diagnosis
Varicella-zoster virus is an important human pathogen that causes varicella after primary infection and zoster after recurrence. Following primary infection, the virus remains latently for life in dorsal root and cranial nerve ganglia.
Sauerbrei, A, Sauerbrei, Andreas
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ABSTRACT Systemic corticosteroids frequently utilized to manage lumbosacral radiculopathy introduce an immunological paradox by potentially triggering varicella‐zoster virus reactivation. While well‐documented in severely immunocompromised populations, the specific neuro‐immunological mechanisms in otherwise immunocompetent patients with lumbar disc ...
Jun Liu +11 more
wiley +1 more source
ABSTRACT An 82‐year‐old woman with JAK2‐mutated myelofibrosis who developed hemoptysis after initiation of ruxolitinib. She presented with anemia and ground‐glass opacities and was treated with antibiotics. She was readmitted with worsening respiratory symptoms. Sputum cultures yielded Mycobacterium avium.
Mataichi Sekiya +3 more
wiley +1 more source
Programmi di vaccinazione anti-varicella negli USA
Gli autori descrivono i principali risultati, ottenuti negli Stati Uniti, a seguito dell’avvio dei programmi di vaccinazione anti-varicella nell’infanzia.
VALLE S., D'ALESSANDRO, Daniela
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Varicella is a benign disorder occurring commonly in children. Hemorrhagic varicella is a serious complication occurring in immunocompromised persons or those on immunosuppressive therapy.
Bala Kumar Dorai +4 more
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