Results 61 to 70 of about 5,659 (257)

Language, creoles, varieties: From emergence to transmission

, 2023
This book offers a selection of papers dealing with second language acquisition, foreign language teaching and creole linguistics inspired by the scientific legacy of Mauritian-born scholar Georges Daniel Véronique (Port-Louis, 1948). An important part of the book is devoted to the description of learner varieties with a focus on sociolinguistic ...
Granget, Cyrille, Repiso, Isabel, Fon Sing, Guillaume   +2 more
openaire   +4 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

On Free $\omega$-Continuous and Regular Ordered Algebras [PDF]

Logical Methods in Computer Science, 2019
We study varieties of certain ordered $\Sigma$-algebras with restricted completeness and continuity properties. We give a general characterization of their free algebras in terms of submonads of the monad of $\Sigma$-coterms.
Zoltan Esik, Dexter Kozen
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Języki regionalne w Polsce na tle europejskim – z perspektywy glottopolitycznej i ekolingwistycznej

Postscriptum Polonistyczne, 2020
The paper discusses and analyses the situation of regional languages in Poland against the background of phenomena taking place in Europe. The phenomena discussed include language extinction, language revival and raising the prestige of linguistic ...
Tomasz Wicherkiewicz
doaj  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Documenting Geographically and Contextually Diverse Language Data Sources

Northern European Journal of Language Technology
Contemporary large-scale data collection efforts have prioritized the amount of data collected to improve large language models (LLM). This quantitative approach has resulted in concerns for the rights of data subjects represented in data collections ...
Angelina McMillan-Major, Francesco De Toni, Zaid Alyafeai, Stella Biderman, Kimbo Chen, Gérard Dupont, Hady Elsahar, Chris Emezue, Alham Fikri Aji, Suzana Ilić, Nurulaqilla Khamis, Colin Leong, Maraim Masoud, Aitor Soroa, Pedro Ortiz Suarez, Daniel van Strien, Zeerak Talat, Yacine Jernite   +17 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source