Results 191 to 200 of about 4,955,430 (314)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Growth, yield and nutrient-use responses of drought-tolerant maize varieties to sowing date and fertilizer microdosing in northern Benin. [PDF]

PLoS One
Yessoufou MWIA, Tovihoudji PG, Zakari S, Akponikpè PBI.   +3 more
europepmc   +1 more source

Mergers, Station Entry, and Programming Variety in Radio Broadcasting [PDF]

Free entry into markets with decreasing average costs and differentiated products can result in an inefficient number of firms and suboptimal product variety.
Joel Waldfogel, Steven T. Berry
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Variety, Consumption and Growth [PDF]

This paper attempts at fixing some guide-posts on the relation between variety, consumption and growth, while abstracting from the well known effect that variety may exert on productivity, through specialization.
Mauro Caminati
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Lightweight CNN and transformer detectors for real-time single-fruit date-variety recognition on edge GPU hardware. [PDF]

PLoS One
Miski A, Alshangiti M.
europepmc   +1 more source

The Cotton Wizard: A Software Implementation of a Cotton Variety Selection Model [PDF]

The Cotton Wizard is an implementation of a cotton variety selection model intended to assist decision-makers (including producers, farm managers, extension specialists, and breeders) in variety selection.
Elam, Emmett W., Reeves, Jeanne M.
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Safety of roasted and ground kernels of an edible variety of Jatropha curcas L. (Xuta) as a traditional food from a third country pursuant to Regulation (EU) No 2015/2283. [PDF]

EFSA J
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Cámara M, Castenmiller J, De Henauw S, Jos Á, Maciuk A, Mangelsdorf I, McNulty B, Naska A, Pentieva K, Siani A, Thies F, Aguilera-Gómez M, Frenzel T, Marcon F, McArdle HJ, Moldeus P, Neuhäuser-Berthold M, Laganaro M, Turla E, Hirsch-Ernst KI.   +23 more
europepmc   +1 more source