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Journal of Biomolecular Structure and Dynamics, 2014 Smallpox was one of the most devastating diseases in the human history and still represents a serious menace today due to its potential use by bioterrorists.
Teodorico C Ramalho, Tanos C C Franca
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17th Century Variola Virus Reveals the Recent History of Smallpox [PDF]
Current Biology, 2016 Smallpox holds a unique position in the history of medicine. It was the first disease for which a vaccine was developed and remains the only human disease eradicated by vaccination.
Ana T Duggan +2 more
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Experimental studies on transformation of the variola virus into the vaccinia virus
Archiv f�r die gesamte Virusforschung, 1963Variola- and alastrim field strains obtained from recent epidemics in India and Africa were inoculated and submitted to passages through heterologous host system in an attempt to obtain transformation into vaccinia virus. We studied in a similar manner variola virus strains cultivated in the embryonated egg, the mouse, and in tissue culture cells ...
A, HERRLICH, A, MAYR, H, MAHNEL, E, MUNZ
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Variola virus is an anthroponotic agent that belongs to the orthopoxvirus family. It is an etiological agent of smallpox, an ancient disease that caused massive mortality of human populations. Twentieth century has witnessed the death of about 300 million people due to the unavailability of an effective vaccine.
Poornima, Gopi +2 more
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Poornima, Gopi +2 more
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The weeping mother, an unusual source of variola virus
Archiv f�r die gesamte Virusforschung, 1967Smallpox virus was isolated from the conjunctiva of 3 out of 4 patients with conjunctivitis during the clinical disease, from none of 5 patients with conjunctivitis in the scabbing stage, and from the conjunctiva of all seven mothers, whose children died of smallpox.
F, Dekking +3 more
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The hemagglutinating activity of the variola virus
Bulletin of Experimental Biology and Medicine, 1958Data on hemagglutinating activity of variola virus are presented in this paper. It was demonstrated that out of 15 types of erythrocytes obtained from various species of animals the virus of smallpox caused mild agglutination only in case of cock erythrocytes.
S. S. Marennikova, E. M. Akatova
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Gene homology between orf virus and smallpox variola virus
Virus Genes, 1996About 47% identity was observed between the deduced amino acid sequences of a protein encoded by a gene of the parapoxvirus orf virus (OV) strain NZ2 and a 6 kDa protein of unknown function reported to be produced by an open reading frame expressed early after infection by the orthopoxvirus Western Reserve vaccinia virus (VAC); the open reading frame ...
A A, Mercer, K M, Fraser, J J, Esposito
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Cytopathogenicity and Propagation of Variola Virus in Tissue Culture
The Journal of Immunology, 1958Summary Variola virus has been shown to induce cytologic changes and to propagate in a variety of human and animal cell strains derived from both normal and malignant tissue. One exception occurred in which the L cell strain was agglutinated by large virus quantities.
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The Infectious Dose of Variola (Smallpox) Virus
Applied Biosafety, 2004Quantitative estimation of an individual's risk of infection due to airborne pathogens requires knowledge of the pathogen's infectious dose, in addition to estimates of the pathogen's airborne conc...
Mark Nicas +3 more
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Screening Studies with Variola Virus
1958Abstract : An investigation was initiated to screen variola virus. The experimental data are concerned with methods of assaying the virus quantitatively, determining optimal conditions for culture growth, and the effect of various physical and chemical reagents on its viability.
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