Results 51 to 60 of about 2,444,251 (292)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Vascular phenotype in angiogenic and non-angiogenic lung non-small cell carcinomas. [PDF]

, 2002
We have previously described a group of non-small cell lung carcinomas without morphological evidence of neo-angiogenesis. In these tumours neoplastic cells fill up the alveoli and the only vessels present appear to belong to the trapped alveolar septa ...
Nicholson, Andrew G., C Ratcliffe, N Singh, P Goldstraw, A G Nicholson, Trivella, M, A Cesario, Granone, Pierluigi, Passalidou, Elisabeth, E Passalidou, Leigh, Irene, Ratcliffe, C, Trivella, Maria-Heleni, Leigh, I, Granone, P, Passalidou, E, Cesario, A, Harris, AL, I Leigh, Nicholson, AG, Pezzella, F, Tetlow, Michelle, Goldstraw, P, Singh, N, J Hu, K C Gatter, Hu, J, Ratcliffe, Cathy, F Pezzella, Goldstraw, Peter, P Granone, A L Harris, Gatter, KC, Singh, Neeta, Gatter, Kevin C., Ferguson, M, Ferguson, Michael, M Trivella, M Ferguson, Tetlow, M, Gatter, Kevin, Pezzella, Francesco, Hu, Jiangting, Harris, Adrian L., M Tetlow, Cesario, Alfredo   +45 more
core   +1 more source

HuR/Cx40 downregulation causes coronary microvascular dysfunction in type 2 diabetes

JCI Insight, 2021
Patients with diabetes with coronary microvascular disease (CMD) exhibit higher cardiac mortality than patients without CMD. However, the molecular mechanism by which diabetes promotes CMD is poorly understood.
Rui Si, Jody Tori O. Cabrera, Atsumi Tsuji-Hosokawa, Rui Guo, Makiko Watanabe, Lei Gao, Yun Sok Lee, Jae-Su Moon, Brian T. Scott, Jian Wang, Anthony W. Ashton, Jaladanki N. Rao, Jian-Ying Wang, Jason X.-J. Yuan, Ayako Makino   +14 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Endothelial Cells Require Related Transcription Enhancer Factor-1 for Cell-Cell Connections Through the Induction of Gap Junction Proteins

, 2012
Objective-Capillary network formation represents a specialized endothelial cell function and is a prerequisite to establish a continuous vessel lumen. Formation of endothelial cell connections that form the vascular structure is regulated, at least in ...
Philbrick, Melissa J, Duffy, Heather S, Cully, Brittany L., Song, Xiaoxiao, An, Xiaojin, He, Ping, Jin, Yi, Philbrick, Melissa J., Jin, Yi,, Wu, Jiaping, Messmer-Blust, Angela, Duffy, Heather S., Xu, Ming, Cully, Brittany L, Li, Jian   +14 more
core   +1 more source

Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility

JCI Insight, 2023
Based upon our demonstration that the smooth muscle cell–selective (SMC-selective) putative methyltransferase, Prdm6, interacts with myocardin-related transcription factor-A, we examined Prdm6’s role in SMCs in vivo using cell type–specific knockout ...
Meng Zou, Kevin D. Mangum, Justin C. Magin, Heidi H. Cao, Michael T. Yarboro, Elaine L. Shelton, Joan M. Taylor, Jeff Reese, Terrence S. Furey, Christopher P. Mack   +9 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Vascular bed molecular profiling by differential systemic decellularization in vivo

, 2018
Objective- Vascular endothelial dysfunction is a key component of several major human diseases, but the molecular basis of this complex disorder has been difficult to determine in vivo.
Ho, Hee Hwa, Park, Jung Eun, Sze, Siu Kwan, Tam, James Pingkwan, Gallart-Palau, Xavier, Lim, Grace Gui Yin, Serra, Aida, Lim, Kah Leong   +7 more
core   +1 more source

Resident phenotypically modulated vascular smooth muscle cells in healthy human arteries. [PDF]

, 2012
Vascular interstitial cells (VICs) are non-contractile cells with filopodia previously described in healthy blood vessels of rodents and their function remains unknown.
Reddy, M, Szewczyk, K, Greenwood, IA, Vasilikostas, G, Harhun, MI, Wan, A, Khong, TK, Ratnasingham, K, Moss, RF, Huggins, CL, Raje, D   +10 more
core   +1 more source

Finite element and mechanobiological modelling of vascular devices [PDF]

, 2011
There are two main surgical treatments for vascular diseases, (i) percutaneous stent deployment and (ii) replacement of an atherosclerotic artery with a vascular graft or tissue engineered blood vessel.
Zahedmanesh, Houman
core   +2 more sources