Results 101 to 110 of about 12,646,548 (407)

The differential diagnosis of chorea [PDF]

, 2007
Chorea is a hyperkinetic movement disorder characterised by excessive spontaneous movements that are irregularly timed, randomly distributed and abrupt. In this article, the authors discuss the causes of chorea, particularly Huntington's disease and the ...
Tabrizi, SJ, Wild, EJ
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways [PDF]

, 2007
Migration and proliferation of smooth muscle cells are key to a number of physiological and pathological processes, including wound healing and the narrowing of the vessel wall.Previous work has shown links between inflammatory stimuli and vascular ...
Agnes Czibula, Andrea R. King, Anthony G. Wilson, Bonventre, Che, Choukroun, David C. Crossman, Du, Emily Heath, Endre Kiss-Toth, Force, Goldschmidt, Grosshans, Hegedus, Hegedus, Hongtao Guan, Hye Youn Sung, Iynedjian, Jones, Ju, Katalin Eder, King, Kiss-Toth, Kiss-Toth, Kiss-Toth, Koo, Lai, Levchenko, Li, Majesky, Mata, McCarthy, Michnick, Mii, Morton, Ohoka, Remy, Remy, Robinson, S. Kim Suvarna, Saka, Sato, Satterthwaite, Schwarzer, Seher, Sheila E. Francis, Stary, Stary, Stary, Steven K. Dower, Surapisitchat, Takeishi, Touyz, Warner, Wilkin, Xia, Yamakawa, Yang, Yue   +58 more
core   +1 more source

Plasma β-amyloid in Alzheimer’s disease and vascular disease

Scientific Reports, 2016
Implementation of amyloid biomarkers in clinical practice would be accelerated if such biomarkers could be measured in blood. We analyzed plasma levels of Aβ42 and Aβ40 in a cohort of 719 individuals (the Swedish BioFINDER study), including patients with
S. Janelidze, E. Stomrud, S. Palmqvist, H. Zetterberg, D. van Westen, A. Jeromin, Linan Song, D. Hanlon, Cristina A. Tan Hehir, D. Baker, K. Blennow, O. Hansson   +11 more
semanticscholar   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Physician perspectives on pulmonary hypertension in ILD: results of a cases-based survey

BMC Pulmonary Medicine
Background Pulmonary hypertension (PH) complicates the course of patients with interstitial lung disease (ILD) in 30–55% of cases and is associated with increased morbidity and mortality. The optimal timing of diagnostic right heart catheterization (RHC)
Ho Cheol Kim, Christopher S. King, Christopher Thomas, Vikramjit Khangoora, Osman Malik, Jared Wilkinson, Shambhu Aryal, Anju Singhal, Alan Nyquist, Oksana A. Shlobin, Steven D. Nathan   +10 more
doaj   +1 more source

Longitudinal Relationships of Subclinical Cardiovascular Disease with Physical Function in Older Adults [PDF]

, 2009
Low ankle-arm index (AAI), a marker of peripheral arterial disease, predicts incident disability in older adults. Elevated pulse wave velocity (PWV), a measure of arterial stiffness, increases risk of cardiovascular events and mortality.
Watson, Nora Lynn
core  

Small Vessel Disease in the Heart and Brain: Current Knowledge, Unmet Therapeutic Need and Future Directions [PDF]

, 2019
No abstract ...
Berry, C, Ford, TJ, Hainsworth, AH, Kaski, JC, Pereira, AC, Sidik, N, Touyz, RM   +6 more
core   +2 more sources

Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease

Oxidative Medicine and Cellular Longevity, 2019
Cardiovascular disease is a leading cause of death and reduced quality of life, proven by the latest data of the Global Burden of Disease Study, and is only gaining in prevalence worldwide.
S. Steven, Katie Frenis, M. Oelze, S. Kalinovic, Marin Kuntić, M. T. Bayo Jiménez, K. Vujacic-Mirski, Johanna Helmstädter, Swenja Kröller-Schön, T. Münzel, A. Daiber   +10 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source