Results 111 to 120 of about 11,507,104 (364)

Annual 12‐Week Dosing Gap of Natalizumab: Clinical Efficacy, Blood Biomarkers, and CSF Cell Composition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich, Tilman Schneider‐Hohendorf, Eric Baetscher, Evan L. Riddle, Marie Deffner, Emily Katsnelson, Janine Ferrant‐Orgettas, Julie Czerkowicz, John Anderson, Susan E. Goelz, Nicholas Schwab   +10 more
wiley   +1 more source

Clinical Observation of Recombinant Human Vascular Endostatin Durative Transfusion Combined with Window Period Arterial Infusion Chemotherapy in the Treatment of 
Advanced Lung Squamous Carcinoma

Chinese Journal of Lung Cancer, 2015
Background and objective Lung cancer is one of the most common malignant tumors in China. The aim of this study is to observe the efficacy and safety of recombinant human vascular endostatin (endostar) durative transfusion combined with window period ...
Yuan LV, Rong JIANG, Chunhua MA, Jinduo LI, Bin WANG, Liwei SUN, Ning MU   +6 more
doaj   +1 more source

Priscol in Treatment of Peripheral Vascular Disease [PDF]

, 1951
J. F. Goodwin, Samuel Kaplan
openalex   +1 more source

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler   +6 more
wiley   +1 more source

Transthyretin cardiac amyloid: Broad heart failure phenotypic spectrum and implications for diagnosis

ESC Heart Failure
Aims Transthyretin cardiac amyloidosis (ATTR‐CA) is most often associated with heart failure with preserved ejection fraction (HFpEF). However, patients may present with impaired systolic function at the time of diagnosis, which has not been widely ...
Mileydis Alonso, Radhika K. Neicheril, Yosef Manla, Malcolm L. McDonald, Alejandro Sanchez, Gabrielle Lafave, Yelenis Seijo De Armas, Antonio Lewis Camargo, Dipan Uppal, David Wolinsky, Nina Thakkar‐Rivera, Mauricio Velez, David A. Baran, Jerry D. Estep, David Snipelisky   +14 more
doaj   +1 more source

VASCULAR DISEASES IN CLINICAL PRACTICE [PDF]

, 1948
Irving S. Wright
openalex   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

Nature Genetics, 1995
P. Frosst, H. J. Blom, R. Milos, P. Goyette, C. Sheppard, R. G. Matthews, G. Boers, M. den Heijer, L. Kluijtmans, L. P. van den Heuve, R. Rozen   +10 more
semanticscholar   +1 more source

Contemporary approach to cardiogenic shock care: a state-of-the-art review

Frontiers in Cardiovascular Medicine
Cardiogenic shock (CS) is a time-sensitive and hemodynamically complex syndrome with a broad spectrum of etiologies and clinical presentations. Despite contemporary therapies, CS continues to maintain high morbidity and mortality ranging from 35 to 50 ...
Aditya Mehta, Ilan Vavilin, Andrew H. Nguyen, Wayne B. Batchelor, Vanessa Blumer, Lindsey Cilia, Lindsey Cilia, Aditya Dewanjee, Mehul Desai, Shashank S. Desai, Michael C. Flanagan, Iyad N. Isseh, Jamie L. W. Kennedy, Katherine M. Klein, Hala Moukhachen, Mitchell A. Psotka, Anika Raja, Carolyn M. Rosner, Palak Shah, Daniel G. Tang, Alexander G. Truesdell, Alexander G. Truesdell, Behnam N. Tehrani, Shashank S. Sinha   +23 more
doaj   +1 more source