Results 11 to 20 of about 1,557,862 (265)

Protein engineering to develop a redox insensitive endothelial nitric oxide synthase

Redox Biology, 2014
The zinc tetrathiolate (ZnS4) cluster is an important structural feature of endothelial nitric oxide synthase (eNOS). The cluster is located on the dimeric interface and four cysteine residues (C94 and C99 from two adjacent subunits) form a cluster with ...
Ruslan Rafikov, Sanjiv Kumar, Saurabh Aggarwal, Daniel Pardo, Fabio V. Fonseca, Jessica Ransom, Olga Rafikova, Qiumei Chen, Matthew L. Springer, Stephen M. Black   +9 more
doaj   +1 more source

Sex Differences in Stroke Subtypes, Severity, Risk Factors, and Outcomes Among Elderly Patients with Acute Ischemic Stroke

Frontiers in Aging Neuroscience, 2015
Background: Although the age-specific incidence and mortality of stroke is higher among men, stroke has a greater clinical effect on women. However, the sex differences in stroke among elderly patients are unknown.
Changshen eYu, Zhongping eAn, Wenjuan eZhao, Wanjun eWang, Chunlin eGao, Shoufeng eLiu, Jinghua eWang, Jialing eWu   +7 more
doaj   +1 more source

Long‐Term Outcomes of Patients With Mediastinal Radiation–Associated Severe Aortic Stenosis and Subsequent Surgical Aortic Valve Replacement: A Matched Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background Cardiac disease after mediastinal radiotherapy for thoracic malignancy (chest radiotherapy [XRT]) often manifests as progressive aortic stenosis. In patients with XRT‐induced severe aortic stenosis undergoing surgical aortic valve replacement (
Eoin Donnellan, Ahmad Masri, Douglas R. Johnston, Gosta B. Pettersson, L. Leonardo Rodriguez, Zoran B. Popovic, Eric E. Roselli, Nicholas G. Smedira, Lars G. Svensson, Brian P. Griffin, Milind Y. Desai   +10 more
doaj   +1 more source

In patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate

Archives of Medical Science, 2019
Introduction Little is known about pathogenetic mechanisms of superficial venous thrombosis (SVT). We aimed to investigate the systemic inflammatory response in the acute phase of SVT, the time course of inflammatory markers and involvement of ...
Pavel Poredoš, Ana Spirkoska, Mateja Kaja Ježovnik   +2 more
doaj   +1 more source

Evaluate the Correlation between the TIMI Frame Count, IMR, and CFR in Coronary Microvascular Disease

Journal of Interventional Cardiology, 2022
Objective. To evaluate the correlation between the TIMI frame count, IMR, and CFR in coronary microvascular disease (slow flow phenomenon). Methods.
Xinye Xu, Jinbao Zhou, Yongzhen Zhang, Qian Li, Lijun Guo, Yanyang Mao, Liyun He   +6 more
doaj   +1 more source

When lymphedema becomes elephantiasis: a multidisciplinary challenge in a patient with severe obesity and cardiopulmonary comorbidities

Veins and Lymphatics
Lymphedema is a progressive condition that can reach an extreme, debilitating stage known as elephantiasis. This case presents a 57-year-old man with stage III by International Society of Lymphology (ISL) lower limb primary lymphedema diagnosed by a ...
Bruno Soggia, Gabriele Fanciulli, Ilaria Manfrini, Jacob Zeitani, Mirko Tessari   +4 more
doaj   +1 more source

Safety and efficacy of larval therapy on treating leg ulcers: a protocol for systematic review and meta-analysis

BMJ Open, 2020
Introduction Leg ulcers (LUs) not only seriously affect life and work of patients, but also bring huge economic burden to the society. As a potential underused biological debridement, larval therapy provides help for the treatment of LUs.
Xiao Yang, Weijing Fan, Baozhong Yang, Xiaoming Hu, Chenyan Shi, Guobin Liu   +5 more
doaj   +1 more source

Prognostic role of MUC5B rs35705950 genotype in patients with idiopathic pulmonary fibrosis (IPF) on antifibrotic treatment

Respiratory Research, 2021
Background A common variant located in the promoter region of MUC5B (rs35705950) is the strongest risk factor for sporadic and familiar IPF, as well as a predictor of outcome.
Davide Biondini, Elisabetta Cocconcelli, Nicol Bernardinello, Giulia Lorenzoni, Chiara Rigobello, Sara Lococo, Gioele Castelli, Simonetta Baraldo, Manuel G. Cosio, Dario Gregori, Marina Saetta, Elisabetta Balestro, Paolo Spagnolo   +12 more
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Circulating choline levels are associated with prognoses in patients with pulmonary hypertension: a cohort study

BMC Pulmonary Medicine, 2023
Backgrounds Mounting evidences have highlighted the association between metabolites and cardiovascular diseases. Our previous works have demonstrated that circulating metabolite, trimethylamine oxide, was associated with prognosis of patients with ...
Yicheng Yang, Beilan Yang, Bingyang Liu, Yanru Liang, Qin Luo, Zhihui Zhao, Zhihong Liu, Qixian Zeng, Changming Xiong   +8 more
doaj   +1 more source

Pharmacological Targeting of the RAGE-NFκB Signalling Axis Impedes Monocyte Activation under Diabetic Conditions through the Repression of SHP-2 Tyrosine Phosphatase Function

Cells, 2023
Monocytes play a vital role in the development of cardiovascular diseases. Type 2 diabetes mellitus (T2DM) is a major CVD risk factor, and T2DM-induced aberrant activation and enhanced migration of monocytes is a vital pathomechanism that leads to ...
Marc Dorenkamp, Madina Nasiry, Dilvin Semo, Sybille Koch, Ivonne Löffler, Gunter Wolf, Holger Reinecke, Rinesh Godfrey   +7 more
doaj   +1 more source