Results 41 to 50 of about 11,970,410 (409)

Prognostic role of MUC5B rs35705950 genotype in patients with idiopathic pulmonary fibrosis (IPF) on antifibrotic treatment

open access: yesRespiratory Research, 2021
Background A common variant located in the promoter region of MUC5B (rs35705950) is the strongest risk factor for sporadic and familiar IPF, as well as a predictor of outcome.
Davide Biondini   +12 more
doaj   +1 more source

Pharmacological Targeting of the RAGE-NFκB Signalling Axis Impedes Monocyte Activation under Diabetic Conditions through the Repression of SHP-2 Tyrosine Phosphatase Function

open access: yesCells, 2023
Monocytes play a vital role in the development of cardiovascular diseases. Type 2 diabetes mellitus (T2DM) is a major CVD risk factor, and T2DM-induced aberrant activation and enhanced migration of monocytes is a vital pathomechanism that leads to ...
Marc Dorenkamp   +7 more
doaj   +1 more source

Safety and efficacy of larval therapy on treating leg ulcers: a protocol for systematic review and meta-analysis

open access: yesBMJ Open, 2020
Introduction Leg ulcers (LUs) not only seriously affect life and work of patients, but also bring huge economic burden to the society. As a potential underused biological debridement, larval therapy provides help for the treatment of LUs.
Xiao Yang   +5 more
doaj   +1 more source

Osteopontin in Vascular Disease: Friend or Foe?

open access: yesArteriosclerosis, Thrombosis and Vascular Biology, 2019
Inflammatory cytokines are necessary for an acute response to injury and the progressive healing process. However, when this acute response does not resolve and becomes chronic, the same proteins that once promoted healing then contribute to chronic ...
Zoe S Lok, A. Lyle
semanticscholar   +1 more source

Vascular Diseases and Gangliosides [PDF]

open access: yesInternational Journal of Molecular Sciences, 2019
Vascular diseases, such as myocardial infarction and cerebral infarction, are most commonly caused by atherosclerosis, one of the leading causes of death worldwide. Risk factors for atherosclerosis include lifestyle and aging. It has been reported that lifespan could be extended in mice by targeting senescent cells, which led to the suppression of ...
Norihiko Sasaki, Masashi Toyoda
openaire   +2 more sources

Interactive effects of vascular risk burden and advanced age on cerebral blood flow. [PDF]

open access: yes, 2014
Vascular risk factors and cerebral blood flow (CBF) reduction have been linked to increased risk of cognitive impairment and Alzheimer's disease (AD); however the possible moderating effects of age and vascular risk burden on CBF in late life remain ...
Bangen, Katherine J   +10 more
core   +1 more source

Inhaled Nanoparticles Accumulate at Sites of Vascular Disease

open access: yesACS Nano, 2017
The development of engineered nanomaterials is growing exponentially, despite concerns over their potential similarities to environmental nanoparticles that are associated with significant cardiorespiratory morbidity and mortality. The mechanisms through
Mark R. Miller   +17 more
semanticscholar   +1 more source

A cross-sectional study of vascular risk factors in a rural South African population : data from the Southern African Stroke Prevention Initiative (SASPI) [PDF]

open access: yes, 2007
Background: Rural sub-Saharan Africa is at an early stage of economic and health transition. It is predicted that the 21st century will see a serious added economic burden from non-communicable disease including vascular disease in low-income countries
A Lee   +48 more
core   +3 more sources

AHA/ACCF Secondary Prevention and Risk Reduction Therapy for Patients with Coronary and other Atherosclerotic Vascular Disease: 2011 update: a guideline from the American Heart Association and American College of Cardiology Foundation.

open access: yesCirculation, 2011
Since the 2006 update of the American Heart Association (AHA)/American College of Cardiology Foundation (ACCF) guidelines on secondary prevention,1 important evidence from clinical trials has emerged that further supports and broadens the merits of ...
Sidney C. Smith   +17 more
semanticscholar   +1 more source

Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms [PDF]

open access: yesCanadian Journal of Cardiology, 2017
Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes.
J. Petrie, T. Guzik, R. Touyz
semanticscholar   +3 more sources

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