Results 61 to 70 of about 7,037,069 (309)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Reduced glomerular filtration rate and its association with clinical outcome in older patients at risk of vascular events: secondary analysis [PDF]

, 2009
<p><b>Background:</b> Reduced glomerular filtration rate (GFR) is associated with increased cardiovascular risk in young and middle aged individuals.
Jukema, J.W., Buckley Brendan M, Chris J Packard, Perry Ivan, De Craen, A.J.M., de Craen Anton J. M, Ian Ford, Ford Ian, Packard Chris J, Ford, I., David J Stott, Sattar Naveed, Buckley, B.M., Stott David J, Sattar, N.A., Bezlyak, V., Westendorp, R.G.J., Packard, C.J., James Shepherd, Jukema J. Wouter, Westendorp Rudi G. J, J Wouter Jukema, Anton J M de Craen, Naveed Sattar, Ivan Perry, Vladimir Bezlyak, Perry, I., Bezlyak Vladimir, Brendan M Buckley, Stott, D.J., Rudi G J Westendorp, Shepherd, J., Shepherd James   +32 more
core   +2 more sources

Correction to: Systemic microvascular rarefaction is correlated with dysfunction of late endothelial progenitor cells in mild hypertension: a substudy of EXCAVATION-CHN1

Journal of Translational Medicine, 2020
Upon publication of the original article [1], it was noticed that Jun Tao’s affiliation information is not complete. The full affiliation information for Jun Tao can be found below and in the complete affiliation list of this Correction article.
Jianwen Liang, Yan Li, Long Chen, Wenhao Xia, Guifu Wu, Xinzhu Tong, Chen Su, Jiang He, Xiufang Lin, Jun Tao   +9 more
doaj   +1 more source

Serum angiopoietin-1 concentration does not distinguish patients with ischaemic stroke from those presenting to hospital with ischaemic stroke mimics

BMC Cardiovascular Disorders, 2022
Background A previous study found that circulating angiopoietin-1 (angpt-1) concentrations were significantly lower in patients who had a recent ischaemic stroke compared to healthy controls.
Joseph V. Moxon, Ann-Katrin Kraeuter, James Phie, Sheryl Juliano, Georgina Anderson, Glenys Standley, Cindy Sealey, Richard P. White, Jonathan Golledge   +8 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Mitochondria in vascular disease [PDF]

Cardiovascular Research, 2012
Mitochondria are often regarded as the powerhouse of the cell by generating the ultimate energy transfer molecule, ATP, which is required for a multitude of cellular processes. However, the role of mitochondria goes beyond their capacity to create molecular fuel, to include the generation of reactive oxygen species, the regulation of calcium, and ...
Emma, Yu, John, Mercer, Martin, Bennett
openaire   +2 more sources

Cathepsin L Promotes Vascular Intimal Hyperplasia after Arterial Injury

Molecular Medicine, 2017
The inflammatory pathways that drive the development of intimai hyperplasia (IH) following arterial injury are not fully understood. We hypothesized that the lysosomal cysteine protease cathepsin L activates processes leading to IH after arterial injury.
Jingjing Cai, Hua Zhong, Jinze Wu, Rui-Fang Chen, Huan Yang, Yousef Al-Abed, Ying Li, Xiaohui Li, Weihong Jiang, Marcelo F. Montenegro, Hong Yuan, Timothy R. Billiar, Alex F. Chen   +12 more
doaj   +1 more source

Transitioning intravenous epoprostenol to oral selexipag in idiopathic pulmonary arterial hypertension: a case report

ESC Heart Failure, 2023
Intravenous (i.v.) prostacyclin is the cornerstone treatment in high‐risk pulmonary arterial hypertension (PAH) patients. Selexipag is an orally available prostacyclin receptor agonist.
André Alexandre, Inês Furtado, Luísa Carvalho, Fabienne Gonçalves, Alzira Melo, Joana Alves, Mário Santos, Abílio Reis   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source