Results 71 to 80 of about 7,037,069 (309)

Vascular mechanical forces and vascular diseases

Journal of Advanced Research
Blood vessels are continuously exposed to mechanical forces, mainly including shear stress, cyclic stretch, and hydrostatic pressure. These forces regulate the functions of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) through complex mechanosensing and signal transduction pathways, which are essential for maintaining vascular ...
Shiwen Liu, Jun Cai, Zhenzhen Chen
openaire   +2 more sources

Fatty acid methyl esters as a potential therapy against cerebral ischemia

Oilseeds and fats, crops and lipids, 2016
Saturated fatty acids have been traditionally thought to be detrimental in circulation. However, we describe the beneficial effects of palmitic and stearic acid methyl esters as it relates to neuroprotection and cerebral vasodilatory properties in global
Hui-Chao Lee Reggie, Goyanes Vasquez Juan Jose, Couto e Silva Alexandre, Klein Daniel D., Valido Stephen E., Chen Joseph A., Lerner Francesca M., Neumann Jake T., Yin-Chieh Wu Celeste, Wen Lin Hung   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events? [PDF]

, 2009
<p><b>Background:</b> Circulating inflammatory markers may more strongly relate to risk of fatal versus nonfatal cardiovascular disease (CVD) events, but robust prospective evidence is lacking.
Jukema, J.W., Westendorp, R.G.J., Lowe, G.D., Murray, H.M., Cobbe, S., de Craen, A.J.M., Blauw, G.J., Ford, I., Welsh, P.I., Murphy, M.B., Buckley, B.M., Macfarlane, P.W., Stott, D.J., Sattar, N.A., Shepherd, J., Gerard J Blauw, Chris J Packard, Ian Ford, Ford Ian, David J Stott, Sattar Naveed, Welsh Paul, Stuart Cobbe, Westendorp Rudi G. J., Lowe Gordon D., Heather M Murray, Paul Welsh, Murphy Michael B., Macfarlane Peter W., Peter W Macfarlane, James Shepherd, Buckley Brendan M., Stott David J., Cobbe Stuart, Jukema J. Wouter, J Wouter Jukema, Murray Heather M., Anton J M de Craen, de Craen Anton J. M., Packard Chris J., Naveed Sattar, Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) Study Group, Blauw Gerard J., Brendan M Buckley, Michael B Murphy, Rudi G J Westendorp, Gordon D Lowe, Shepherd James   +47 more
core   +2 more sources

Impact of patient positioning on hemodynamic assessment: A comparison of supine and upright right heart catheterization

Physiological Reports
The impact of patient positioning on PCWP measurement and PH classification is underexplored. This study evaluates the differences in hemodynamic assessments between supine and upright RHC.
Mohammed A. Chowdhury, Johanna Squires, David M. Systrom, Aaron B. Waxman   +3 more
doaj   +1 more source

The association between the “T” vein and ulceration of the lateral aspect of the leg

Veins and Lymphatics
The “T” vein is a tributary of The Great Saphenous Vein (GSV) located in the upper third of the leg with a perpendicular course to the GSV. It usually crosses the tibial bone and feeds by reflux of varicose veins of the lateral aspect of the leg.
Paolo Eusebi, Ilaria Massi, Francesca Alesiani, Mirko Tessari   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Inositol in the MAnaGemENt of abdominal aortic aneurysm (IMAGEN): study protocol for a randomised controlled trial

Trials, 2017
Background An abdominal aortic aneurysm (AAA) is a focal dilation of the abdominal aorta and is associated with a risk of fatal rupture. Experimental studies suggest that myo-inositol may exert beneficial effects on AAAs through favourable changes to ...
Sophie E. Rowbotham, Jenna L. Pinchbeck, Georgina Anderson, Bernie Bourke, Michael Bourke, T. Christian Gasser, Rene Jaeggi, Jason S. Jenkins, Corey S. Moran, Susan K. Morton, Christopher M. Reid, Ramesh Velu, Lisan Yip, Joseph V. Moxon, Jonathan Golledge   +14 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source