Results 121 to 130 of about 3,228,182 (380)

Vascular endothelial growth factor in eye disease

Progress in Retinal and Eye Research, 2008
Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision loss in developed countries. In the U.S., for example, retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration are the principal causes of blindness in the infant, working age and elderly populations, respectively.
M.E. Hartnett, John S. Penn, Manuela Bartoli, Robert W. Caldwell, A. Madan, Ruth B. Caldwell   +5 more
openaire   +4 more sources

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Inhibition of renal cell carcinoma angiogenesis and growth by antisense oligonucleotides targeting vascular endothelial growth factor [PDF]

Angiogenesis is critical for growth and metastatic spread of solid tumours. It is tightly controlled by specific regulatory factors. Vascular endothelial growth factor has been implicated as the key factor in tumour angiogenesis.
A Takahashi, AA Baccala, AL Harris, AP Smyth, B Belletti, CA Stein, CJ Drake, D Hanahan, D Mercola, D W Siemann, DP Berger, DW Leung, F Tang, G Gasparini, G Perletti, HH Engelhard, J Denekamp, J Folkman, J Folkman, J Folkman, J Jacobsen, J Mordenti, JK McLaughlin, JT Nguyen, K Maeda, K Sato, K Sato, KA Houck, KH Plate, KJ Kim, LF Hennequin, LM Ellis, M Asano, M Saleh, M Toi, M Tomisawa, MA Kang, MI Phillips, MS O'Reilly, MS O'Reilly, MS O'Reilly, N Ferrara, N Weidner, P Borgstrom, P Giannakakou, P Lin, P Workman, R Bicknell, R Masood, R Masood, S Soker, S Yoshino, SY Cheng, T Ishizuka, T Nakashima, V Paradis, W Risau, W Shi, Y Eguchi, Y Wang, YA Sidky, YS Gho   +61 more
core   +2 more sources

Evaluation of anticancer peptide VEGF111b secretion in HEK293 human cells

Fiyz̤, 2017
Background: VEGF111b is a new isoform of vascular endothelial growth factor (VEGF) recently considered as a new anticancer drug. The aim of this study was to evaluate the VEGF111b secretion from HEK293 cell wall in order to commercial production of this ...
Morteza Sadeghi , Zohreh Hojati
doaj  

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Development of a Computationally Optimized Model of Cancer-induced Angiogenesis through Specialized Cellular Mechanics [PDF]

arXiv, 2016
Angiogenesis, the development of new vasculature, is a critical process in the growth of new tumors. Driven by a goal to understand this aspect of cancer proliferation, I develop a discrete computationally optimized mathematical model of angiogenesis that specializes in intercellular interactions.
arxiv  

3D CA model of tumor-induced angiogenesis [PDF]

arXiv, 2020
Tumor-induced angiogenesis is the formation of new sprouts from preexisting nearby parent blood vessels. Computationally, tumor-induced angiogenesis can be modeled using cellular automata (CA), partial differential equations, etc. In this present study, a realistic physiological approach has been made to model the process of angiogenesis by using 3D CA
arxiv  

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin [PDF]

, 2016
© 2016 Taylor & Francis. Aim of the Study: Bleomycin-induced lung disease is a serious complication of therapy characterized by alveolar injury, cytokine release, inflammatory cell recruitment, and eventually pulmonary fibrosis.
Crooks, Michael G., Greenman, John, Hart, Simon P., Sadofsky, Laura R., Williamson, James D.   +4 more
core   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source