Results 221 to 230 of about 845,562 (305)

A Biologic Hybrid Approach Combining Superior Capsular Reconstruction, Long Head of the Biceps Tendon Rerouting, and Rotator Cuff Repair

open access: yesArthroscopy Techniques, EarlyView.
Abstract Large to massive posterior superior rotator cuff tears remain challenging to treat because chronic tendon retraction, fatty degeneration, and muscle atrophy often preclude durable repair. Superior capsular reconstruction using fascia lata autograft has been introduced to restore superior glenohumeral stability; however, graft failure, donor ...
Bo Taek Kim   +3 more
wiley   +1 more source

Applying machine learning to pharmacovigilance data: A proof‐of‐concept study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Machine learning (ML) applications in pharmacovigilance remain limited and underexplored. Using data from the French National pharmacovigilance database (FNPV), this proof‐of‐concept study aimed to assess the feasibility of using a ML algorithm—eXtreme Gradient Boosting (XGBoost)—combined with SHapley Additive exPlanations (SHAP) analysis, to ...
Romain Barus   +6 more
wiley   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu   +23 more
wiley   +1 more source

Staged matrix and micrografting reconstruction for no-option CLTI: A case report. [PDF]

open access: yesSci Prog
Miserlis D   +4 more
europepmc   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu   +3 more
wiley   +1 more source

Adipose tissue for reconstruction and wound healing: applications, challenges, and future directions. [PDF]

open access: yesFront Cell Dev Biol
Kondej K   +5 more
europepmc   +1 more source

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