Results 71 to 80 of about 4,437,433 (360)

Persistence of inflammatory and vascular mediators 5 months after hospitalization with COVID-19 infection

Frontiers in Medicine, 2023
Background and aimIn acute severe COVID-19, patients present with lung inflammation and vascular injury, accompanied by an exaggerated cytokine response.
James Melhorn, James Melhorn, Asma Alamoudi, Alexander J. Mentzer, Alexander J. Mentzer, Emily Fraser, Anastasia Fries, Mark Philip Cassar, Mark Philip Cassar, Andrew Kwok, Andrew Kwok, Julian Charles Knight, Julian Charles Knight, Julian Charles Knight, Julian Charles Knight, Betty Raman, Betty Raman, Nick P Talbot, Nick P Talbot, Nick P Talbot, Nayia Petousi, Nayia Petousi, Nayia Petousi   +22 more
doaj   +1 more source

Effects of balloon injury on neointimal hyperplasia in steptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted rats. [PDF]

, 2001
BACKGROUND: The mechanisms of increased neointimal hyperplasia after coronary interventions in diabetic patients are still unknown. METHODS AND RESULTS: Glucose and insulin effects on in vitro vascular smooth muscle cell (VSMC) proliferation and ...
Carriero M.V., Cavuto L., Chiariello M., Chieffo A., Coppola C., Davalli A.M., Di Lorenzo E., ESPOSITO, GIOVANNI, Indolfi C., Pardo F., PERRINO, CINZIA, RAPACCIUOLO, ANTONIO, STABILE, EUGENIO, Torella D.   +13 more
core  

Angiogenesis-dependent and independent phases of intimal hyperplasia. [PDF]

, 2004
BACKGROUND: Neointimal vascular smooth muscle cell (VSMC) proliferation is a primary cause of occlusive vascular disease, including atherosclerosis, restenosis after percutaneous interventions, and bypass graft stenosis. Angiogenesis is implicated in the
Bhardwaj, S, De Muinck, E, Ferrara, N, Khurana, R, Martin, JF, Murakami, M, Simons, M, Yla-Herttuala, S, Zachary, I, Zhuang, Z   +9 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Mebendazole reduces vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice.

PLoS ONE, 2014
Mebendazole is an antihelminthic drug that exerts its effects via interference with microtubule function in parasites. To determine the utility of mebendazole as a potential treatment for vascular diseases involving proliferation of vascular smooth ...
Jintao Wang, Hui Wang, Chiao Guo, Wei Luo, Alyssa Lawler, Aswin Reddy, Julia Wang, Eddy B Sun, Daniel T Eitzman   +8 more
doaj   +1 more source

miR-135a-5p overexpression in peripheral blood-derived exosomes mediates vascular injury in type 2 diabetes patients

Frontiers in Endocrinology, 2023
ObjectiveDiabetes pathology relies on exosomes (Exos). This study investigated how peripheral blood Exo-containing microRNAs (miRNAs) cause vascular injury in type 2 diabetes (T2D).MethodsWe removed DEmiRNA from T2D chip data from the GEO database.
Kangling Xie, Cui Li, Mingzhu Wang, Siqian Fu, Ying Cai   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Technical and Conceptual Review on the L5-S1 Oblique Lateral Interbody Fusion Surgery (OLIF51)

Spine Surgery and Related Research, 2021
Lumbar lateral interbody fusion (LLIF) has been gaining popularity among the spine surgeons dealing with degenerative spinal diseases while LLIF on L5-S1 is still challenging for its technical and anatomical difficulty.
Sumihisa Orita, Yasuhiro Shiga, Kazuhide Inage, Yawara Eguchi, Satoshi Maki, Takeo Furuya, Yasuchika Aoki, Masahiro Inoue, Richard A. Hynes, Masao Koda, Hiroshi Takahashi, Tsutomu Akazawa, Junichi Nakamura, Shigeo Hagiwara, Gen Inoue, Masayuki Miyagi, Shunsuke Fujibayashi, Takahiro Iida, Yoshihisa Kotani, Masato Tanaka, Takao Nakajima, Seiji Ohtori   +21 more
doaj   +1 more source

Platelets and galectins [PDF]

, 2014
A major function of platelets is keeping the vascular system intact. Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug.
Schattner, Mirta Ana
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source