Results 51 to 60 of about 4,437,433 (360)

Popliteal vascular injuries

Surgical Clinics of North America, 2002
Popliteal vascular injury remains one of the most difficult diagnostic and therapeutic challenges for trauma surgeons. Only with strict attention to rapid diagnosis; early surgical treatment with meticulous technical skill; and aggressive use of various adjunctive measures, such as completion arteriography, anticoagulation, fasciotomy, and proper ...
Department of Surgery, University of Florida College of Medicine Jacksonville, Florida USA ( host institution ), Frykberg, Eric R ( author )   +1 more
openaire   +3 more sources

Outcomes of truncal vascular injuries in children. [PDF]

, 2009
BACKGROUND: Pediatric truncal vascular injuries occur infrequently and have a reported mortality rate of 30% to 50%. This report examines the demographics, mechanisms of injury, associated trauma, and outcome of patients presenting for the past 10 years ...
Abujamra, Ali, Anderson, Andrea Hayes-Jordan, Asensio, Asensio, Bergqvist, Buckman, Burch, Burjonrappa, Carrillo, Charles S. Cox, Choit, Christopher M. Anderson, Cooper, Cox, Cox, de Virgilio, DeCou, Fayiga, Haan, Hall, Horwitz, Huerta, Karmy-Jones, Kevin P. Lally, Klein, Klinkner, Kuehne, Kuo-Jen Tsao, McCarthy, Meagher, Milas, Milas, Moainie, Myers, Nashef, Nathan D. Allison, Ombrellaro, Pearl, Puapong, Reed, Reichard, Richard J. Andrassy, Richardson, Riches, Riesenman, Roth, Rozycki, Shaker, Shinil K. Shah, Sirinek, Takach, Tiao, Trachiotis, Whitehouse, Whitson, Wiencek, Wildhaber, Wilson, Wolf, Woo   +61 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Lycium barbarum polysaccharide inhibits Hcy-induced vascular smooth muscle cells migration and invasion via upregulation of KLF4

Scientific Reports
This study examined the potential protective effects of Lycium barbarum polysaccharide (LBP) in opposing homocysteine (Hcy)-triggered vascular smooth muscle cells (VSMCs) migration and invasion.
Xinpeng Ma, Xiuyu Wang, Tingrun Mo, Xing Ma, Minghao Zhang   +4 more
doaj   +1 more source

The mechanism by which piR-000699 targets SLC39A14 regulates ferroptosis in aging myocardial ischemia/reperfusion injury

Acta Biochimica et Biophysica Sinica
Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to different types of cell death.
Chi Hongyang, Chai Yue’e, Ma Lingju, Wang Yichen, Wu Qianqian, Wang Lexin, Zhai Junjie, Ma Fufun, Tian Yancheng, Qi Ning, Peng Jianhong, Fu Youjuan, Yang Xiaoling, Huang Hui, Ma Shengchao   +14 more
doaj   +1 more source

Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. [PDF]

, 2019
Disruption of the blood-brain barrier (BBB) is critical to initiation and perpetuation of disease in multiple sclerosis (MS). We report an interaction between oligodendroglia and vasculature in MS that distinguishes human white matter injury from normal ...
Baranzini, Sergio E, Chan, Jonah R, Fancy, Stephen PJ, Hoi, Kimberly K, Huang, Nanxin, Kim, Kicheol, Niu, Jianqin, Tsai, Hui-Hsin, Xiao, Lan, Yu, Guangdan   +9 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Knockdown of lncRNA XR_877193.1 suppresses ferroptosis and promotes osteogenic differentiation via the PI3K/AKT signaling pathway in SONFH

Acta Biochimica et Biophysica Sinica
Ferroptosis is a novel form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxides. Recent research has suggested that ferroptosis in osteoblasts contributes to steroid-induced osteonecrosis of the femoral head (SONFH)
Yang Huixia, Ding Ning, Qing Shi, Hao Yinju, Zhao Cilin, Wu Kai, Li Guizhong, Zhang Huiping, Ma Shengchao, Bai Zhigang, Jiang Yideng   +10 more
doaj   +1 more source

The roles of endoglin gene in cerebrovascular diseases. [PDF]

, 2017
Endoglin (ENG, also known as CD105) is a transforming growth factor β (TGFβ) associated receptor and is required for both vasculogenesis and angiogenesis.
Ma, Li, Su, Hua, Zhang, Rui, Zhu, Wan
core   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source