Results 71 to 80 of about 841,585 (286)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Comment on Kilian et al. Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. J. Clin. Med. 2023, 12, 2704 [PDF]

, 2023
We read with interest the recent article by Killian et al. regarding the characteristics and treatment of brain vascular malformations (VMs) in children and adults with hereditary hemorrhagic telangiectasia (HHT) [...
Boccardi, Edoardo, Dupuis-Girod, Sophie, Shovlin, Claire L, Sophie Dupuis-Girod, Omer F. Eker, Edoardo Boccardi, Eker, Omer F, Claire L. Shovlin   +7 more
core   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Vascular lesions: Hemangioma or venous malformation?

Radiology Case Reports
We present a case of a 62-year-old female who was incidentally found to have a venous malformation. Venous malformations are part of a larger category of slow flow vascular malformations and are associated with various familial syndromes and localized ...
Brandon Thinh Duc Dang, MD, Alan Victor Krauthamer, MD   +1 more
doaj   +1 more source

Biodegradable and Biocompatible Functional Polymers for Biomedical Applications

Advanced Functional Materials, EarlyView.
Biodegradable and biocompatible functional polymers integrate electrical, mechanical, and stimuli‐responsive functionalities while enabling programmed degradation under physiological conditions. This review introduces recent advances in conductive, shape‐memory, self‐healing, photocurable, and adhesive polymer systems, emphasizing material design ...
Won Bae Han, Shuvra Mondal, Sungkeun Han, Chan‐Hwi Eom, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +5 more
wiley   +1 more source

Genetic aspects of vascular malformations

Vascular anomalies are a heterogenous group of diseases that include vascular tumours and vascular malformations. Over the past two decades, significant progress has been made in elucidating the genetic basis of these anomalies, leading to improved ...
Boon, Laurence M., Revencu, Nicole, Vikkula, Miikka, Coulie, Julien   +3 more
core   +1 more source

Vascular malformations: a hospital based study [PDF]

, 2019
Background: Vascular anomalies comprise a widely heterogeneous group of lesions. Diagnosis and management of these lesions present challenges to the surgeons, radiologists and histopathologists.
Prasad, Uma, Sunilkumar, Komanapalli, Sudhakar, P. V., Atla, Bhagyalakshmi, Jena, Unmesh Kumar, Aithal, Karthik   +5 more
core   +1 more source

Poisson's Ratio‐Driven Control of Myogenic Differentiation and Maturation in Auxetic Metamaterials under Dynamic Mechanical Stimulation

Advanced Functional Materials, EarlyView.
This study explored how innovative “auxetic” scaffolds, which expand when stretched, influence skeletal muscle development. Researchers cultured muscle cells on different scaffold designs and applied repeated stretching over 10 days. They found that scaffold geometry affected muscle cell differentiation and fiber formation.
Maria Kalogeropoulou, Prabhdeep Kaur, Monica Boffito, Pierpaolo Fucile, Gianluca Ciardelli, Lorenzo Moroni   +5 more
wiley   +1 more source

Klippel–Trenaunay syndrome with arterio-veno-lymphatic malformation: A rare presentation

Indian Dermatology Online Journal, 2020
Klippel–Trenaunay syndrome (KTS) is a rare disorder characterized by triad of vascular malformations, varicose veins, and bony or soft tissue hypertrophy involving an extremity.
Bhagyashree B Supekar, Apoorva D Chopkar, Vaishali H Wankhade, Rajesh Pratap Singh, Dharitri Mukund Bhat, Parvathy Suresh   +5 more
doaj   +1 more source

Biodegradable Conductors for Implantable and Wearable Transient Bioelectronics

Advanced Functional Materials, EarlyView.
Biodegradable conductors are essential building blocks for transient bioelectronics, enabling temporary sensing, stimulation, and energy transfer while eliminating the need for device retrieval. This review summarizes biodegradable metals, conducting polymers, ionic conductors, and conductive composites, highlighting degradation mechanisms, material ...
Yicheng Zhu, Yijun Liu, Naoji Matsuhisa
wiley   +1 more source