Results 91 to 100 of about 736,788 (295)

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Comparison of ultrasound features and lesion sites in dysfunctional arteriovenous fistula

Renal Failure
This study aimed to investigate ultrasound features of arteriovenous fistula stenosis and their relationship with primary patency after percutaneous transluminal angioplasty (post-intervention primary patency) and compare this classification with that ...
Yin Wang, Xiao-mei Huang, Yi Zhang, Jingjing Li, Jun Li, Zheng Ye, Yu Peng, Xian-jin Zhang, Na Tang, Wen-wen Qiu, Li Xu   +10 more
doaj   +1 more source

Long-Term Management of Vascular Access Ports in Nonhuman Primates Used in Preclinical Efficacy and Tolerability Studies

Journal of Investigative Surgery, 2020
Vascular access ports (VAPs) are an essential tool for long-term vascular access in preclinical studies and disease modeling in non-human primates (NHPs).
Lucas A. Mutch, Samuel T. Klinker, Jody J. Janecek, Melanie N. Niewinski, Rachael M. Z. Lee, Melanie L. Graham   +5 more
doaj   +1 more source

Role of renal vascular coordinator on access flow dysfunction: A quality improvement initiative on improving patency rate

A renal vascular coordinator (RVC) is a single point-of-contact allied health professional in the early detection and timely intervention of flow dysfunction.
Yan Lun, Allen Liu, Lim Zhi Ting, Mary, Kong May Ching, Cathrine, Chung Cheen, Chai   +3 more
core   +1 more source

Vascular Targeted Agents for the Treatment of Angiosarcoma [PDF]

, 2013
Background: Angiogenesis is the process of new blood vessel formation, and is regulated by angiogenic growth factors including vascular endothelial growth factor (VEGF). Angiosarcomas are rare, aggressive vascular tumours.
P J Woll (16226153), R J Young (13425891), C A Staton (16226156), Malcolm Reed (4465876), Young, Robin, N J Brown (13424178)   +5 more
core  

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Comparison of Axillary Loop and Straight Grafts Patency and Their Complications for Hemodialylis Access

Armaghane Danesh Bimonthly Journal, 2011
Introduction & Objective: Dialysis vascular access complications are important causes of morbidity in chronic hemodialysis patients. The aim of the present study was a comparison of auxiliary loop and atraight grafts patency and its complications for ...
J KHoshnevis, M Samsami, AH Jalali, M Falahzavareh, F Hoseinizadegan Shirazi, F Hoseinizadegan Shirazi   +5 more
doaj  

Determinants of patency of arteriovenous fistula in hemodialysis patients

Saudi Journal of Kidney Diseases and Transplantation, 2018
The arteriovenous fistula (AVF) is the vascular access of the first choice for hemodialysis (HD). Studies on patency of AVF and its affecting factors reveal a high risk for access failure. The aim of this study was to assess the primary and secondary AVF
Mohamed Karim Zouaghi, Mohamed Ali Lammouchi, Mohaned Hassen, Lamia Rais, Madiha Krid, Wided Smaoui, Hela Jebali, Rania Kheder, Fethi Ben Hamida, Fatma Ben Moussa, Lilia Ben Fatma, Soumaya Beji   +11 more
doaj   +1 more source

Patency and effectiveness of vascular access for hemodialysis patients: a descriptive study

Polish Journal of Cardio-Thoracic Surgery
Vascular access is one of the most important issues affecting the quality of life of patients who are dialysis-dependent.The aim of our study was to determine the infection rates of permanent catheters. We also evaluated the thrombosis, maturation time, and patency rates of arteriovenous fistulas based on their location in the arm in dialysis patients ...
Cetinkaya, Ferit, Tas, Ayse
openaire   +2 more sources

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source