Results 61 to 70 of about 2,306,257 (312)

The differential effects of CBD and CBDA on viability and mRNA expression in colorectal cancer cells

Journal of Cannabis Research
Background Cannabinoids have attracted significant attention for their potential therapeutic application in cancer research. However, recent studies have reported antitumor activity of cannabidiolic acid (CBDA)—the acidic precursor of CBD—in breast ...
Christine Heinzle, Kathrin Geiger, Reinhard Ertl, Eva Maria Brandtner, Andreas Leiherer, Stella Gaenger, David Schmidmayr, Heinz Drexel, Axel Muendlein   +8 more
doaj   +1 more source

A role of TDIF peptide signaling in vascular cell differentiation is conserved among euphyllophytes

Frontiers in Plant Science, 2015
Peptide signals mediate a variety of cell-to-cell communication crucial for plant growth and development. During Arabidopsis thaliana vascular development, a CLE (CLAVATA3/EMBRYO SURROUNDING REGION-related) family peptide hormone, TDIF (tracheary element
Yuki eHirakawa, Yuki eHirakawa, John L Bowman, John L Bowman   +3 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Vascular anomalies of the head and neck in children. [PDF]

, 2015
Sixty percent of vascular anomalies in children are found in the head and neck. These lesions can present throughout antenatal, perinatal and childhood development. They broadly fall into two categories: vascular tumours and vascular malformations. Their
Mahady, Kate, Berkeley, Rupert, Barnacle, Alex, Mankad, Kshitij, Stuart, Sam, Robertson, Fergus, Thust, Stefanie   +6 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Spatial Pattern Analysis and Conservation Assessment of Apiaceae in Mongolia

Plants
The family Apiaceae, distributed throughout the Northern Hemisphere, is the largest family of angiosperms. However, little is known about the conservation status, diversity, and distribution of Apiaceae species in Mongolia. This study had two main aims: (
Magsar Urgamal, Shukherdorj Baasanmunkh, Zagarjav Tsegmed, Batlai Oyuntsetseg, Chuluunbat Javzandolgor, Sheng-Xiang Yu, Jung-Won Yoon, Magdalena G. W. Cygan, Hyeok Jae Choi   +8 more
doaj   +1 more source

The protected flora of long‐established cemeteries in Hungary: Using historical maps in biodiversity conservation

Ecology and Evolution, 2020
The role of anthropogenically influenced habitats in conserving elements of the original wildlife has increased worldwide simultaneously with the disappearance of natural sites.
Viktor Löki, András Schmotzer, Attila Takács, Kristóf Süveges, Ádám Lovas‐Kiss, Balázs András Lukács, Jácint Tökölyi, Attila Molnár V.   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Compilation and research journey of “Flora of Guangxi” — Also discussing the development vision for plant taxonomy and related disciplines in Guangxi

Guangxi Zhiwu
Guangxi is located in the south of China, with complex geology, diverse terrain, and abundant biodiversity, also serving as a vital ecological barrier in southern China.
XU Weibin, LIU Yan*, WEI Fanan
doaj   +1 more source