Results 61 to 70 of about 2,421,117 (307)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Algoflora and vascular flora of a limestone spring in the Warta river valley

Acta Societatis Botanicorum Poloniae, 2011
Qualitative analysis of algae, including microhabitats and vascular vegetation in a spring niche, together with basic physical and chemical characteristics is presented. 175 diatom taxa as well as taxa of macroalgae and vascular plants were determined in
Joanna Żelazna-Wieczorek, Monika Mamińska   +1 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The differential effects of CBD and CBDA on viability and mRNA expression in colorectal cancer cells

Journal of Cannabis Research
Background Cannabinoids have attracted significant attention for their potential therapeutic application in cancer research. However, recent studies have reported antitumor activity of cannabidiolic acid (CBDA)—the acidic precursor of CBD—in breast ...
Christine Heinzle, Kathrin Geiger, Reinhard Ertl, Eva Maria Brandtner, Andreas Leiherer, Stella Gaenger, David Schmidmayr, Heinz Drexel, Axel Muendlein   +8 more
doaj   +1 more source

A role of TDIF peptide signaling in vascular cell differentiation is conserved among euphyllophytes

Frontiers in Plant Science, 2015
Peptide signals mediate a variety of cell-to-cell communication crucial for plant growth and development. During Arabidopsis thaliana vascular development, a CLE (CLAVATA3/EMBRYO SURROUNDING REGION-related) family peptide hormone, TDIF (tracheary element
Yuki eHirakawa, Yuki eHirakawa, John L Bowman, John L Bowman   +3 more
doaj   +1 more source

Cultivation cost-benefit analysis of some important medicinal plants in Serbia [PDF]

, 2020
Driven by frequent media misinformation about the level of profitability of growing certain medicinal plants, in this paper we presented a cost-benefit analysis based on twenty years of experience in field production.
Pljevljakušić, Dejan***dpljevljakusic@mocbilja.rs***Institute for Medicinal Plants Research "Dr. Josif Pančić", Belgrade***http://orcid.org/0000-0003-2362-8290, Brkić, Sreta***sbrkic@mocbilja.rs***Institute for Medicinal Plants Research "Dr. Josif Pančić", Belgrade***, Dejan Pljevljakušić, Sreta Brkić   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures [PDF]

, 2010
Background The xylem vascular system is composed of fused dead, hollow cells called tracheary elements (TEs) that originate through trans-differentiation of root and shoot cambium cells. TEs undergo autolysis as they differentiate and mature.
Elena T Iakimova, Ernst J Woltering, Twumasi, P., Emons, A.M.C., Wim van Ieperen, Olaf van Kooten, Iakimova, E.T., Qian, T., Schel, J.H.N., Peter Twumasi, Tian Qian, Woltering, E.J., Anne Emons, Kooten, O., van, Ieperen, W., van, Anne MieC Emons, Jan HN Schel   +16 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source