Results 101 to 110 of about 5,118,564 (403)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The value of transcranial Doppler derived pulsatility index for diagnosing cerebral small-vessel disease

Advanced Biomedical Research, 2015
Background: The pulsatility index (PI), measured by transcranial Doppler (TCD) ultrasonography, can reflect vascular resistance induced by cerebral small-vessel disease (SVD).
Abbas Ghorbani, Mohammad Javad Ahmadi, Hamidreza Shemshaki   +2 more
doaj   +1 more source

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I

European Heart Journal, 2013
Hyperglycemia and insulin resistance are key players in the development of atherosclerosis and its complications. A large body of evidence suggest that metabolic abnormalities cause overproduction of reactive oxygen species (ROS).
F. Paneni, J. Beckman, M. Creager, F. Cosentino   +3 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The normal ranges of cardiovascular parameters measured using the ultrasonic cardiac output monitor [PDF]

, 2017
The ultrasonic cardiac output monitor (USCOM) is a noninvasive transcutaneous continuous wave Doppler method for assessing hemodynamics. There are no published reference ranges for normal values in adults (aged 18– 60 years) for this device.
Cattermole, Giles N, Chan, Cangel P.Y, Chan, Stewart S.W, Graham, Colin A, Ho, Grace Y.L, Lau, Peach W.S, Leung, P.Y Mia, Rainer, Timothy H, Smith, Brendan E   +8 more
core   +2 more sources

Haemodynamic changes during prone positioning in anaesthetised chronic cervical myelopathy patients

Indian Journal of Anaesthesia, 2019
Background and Aims: Anaesthetised patients, when positioned prone, experience hypotension and reduction in cardiac output. Associated autonomic dysfunction in cervical myelopathy patients predisposes them to haemodynamic changes.
Nitin Manohar, Venkatapura J Ramesh, Muthuchellappan Radhakrishnan, Dhritiman Chakraborti   +3 more
doaj   +1 more source

Clinical application of pulmonary vascular resistance in patients with pulmonary arterial hypertension

Journal of Cardiothoracic Surgery, 2021
Pulmonary arterial hypertension is a type of malignant pulmonary vascular disease, which is mainly caused by the increase of pulmonary vascular resistance due to the pathological changes of the pulmonary arteriole itself, which eventually leads to right ...
Jianying Deng
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Cardiovascular Effects of a Glycosylated Flavonoids-Rich Leaf Extract from Brazilian Erythroxylum campestre: A Potential Health Bio-Input

Pharmaceuticals
Background: Bioactivity assessments of plant-derived products can benefit human and animal health, especially in regions with vast plant diversity. This study focused on chemical and cardiovascular analyses of Erythroxylum campestre A. St. Hil.
Letícia Henrique Dantas Gomes de Lima, Marcos Willian Francelino Gomes, Thays Siqueira de Sá Curado, Lara Marques Naves, Stefanne Madalena Marques, Marilene Silva Oliveira, John Ihayi Ogbu, Antonio Carlos Severo Menezes, Giuliana Muniz Vila Verde, James Oluwagbamigbe Fajemiroye, Gustavo Rodrigues Pedrino   +10 more
doaj   +1 more source

Persuasive antimicrobial stewardship intervention in the context of a KPC outbreak: a controlled interrupted time series analysis

Antimicrobial Resistance and Infection Control, 2020
Introduction Antimicrobial resistance is a major public health threat. Antimicrobial stewardship (AMS) is one of the key strategies to overcome resistance, but robust evidence on the effect of specific interventions is lacking.
Nuno Rocha-Pereira, Paulo Figueiredo Dias, Sofia Correia, Shirin Shahriari, João Neves, José Teixeira, José Artur Paiva, Carlos Lima Alves, Ana Azevedo   +8 more
doaj   +1 more source