Circulatory contributors to the phenotype in hereditary hemorrhagic telangiectasia [PDF]
Hereditary hemorrhagic telangiectasia (HHT) is mechanistically and therapeutically challenging, not only because of the molecular and cellular perturbations that generate vascular abnormalities, but also the modifications to circulatory physiology that ...
Shovlin, CL
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Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways [PDF]
Chemerin and its G protein-coupled receptor [chemerin receptor 23 (ChemR23)] have been associated with endothelial dysfunction, inflammation, and insulin resistance.
Alves-Lopes, Rheure +9 more
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Natriuretic peptides and cardiovascular damage in the metabolic syndrome. Molecular mechanisms and clinical implications [PDF]
Natriuretic peptides are endogenous antagonists of vasoconstrictor and salt- and water-retaining systems in the body's defence against blood pressure elevation and plasma volume expansion, through direct vasodilator, diuretic and natriuretic properties ...
ALONZO, ALESSANDRO +4 more
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Doppler sonography of the uterine and the cubital arteries in normal pregnancies, preeclampsia and intrauterine growth restriction: evidence for a systemic vessel involvement [PDF]
Aims: The decrease in uterine resistance during normal pregnancy is known to be related to invading trophoblast cells which derive from placental tissue. Uterine and peripheral resistance is elevated in preeclampsia.
Friese, Klaus +4 more
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MicroRNAs in pulmonary arterial remodeling [PDF]
Pulmonary arterial remodeling is a presently irreversible pathologic hallmark of pulmonary arterial hypertension (PAH). This complex disease involves pathogenic dysregulation of all cell types within the small pulmonary arteries contributing to vascular ...
A Courboulin +137 more
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Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity [PDF]
Obesity is associated with increased risk of premature death, morbidity, and mortality from several cardiovascular diseases (CVDs), including stroke, coronary heart disease (CHD), myocardial infarction, and congestive heart failure.
Costa, Rafael M. +3 more
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Insights into the pulmonary vascular complications of heart failure with preserved ejection fraction [PDF]
Pulmonary hypertension in the setting of heart failure with preserved ejection fraction (PH-HFpEF) is a growing public health problem that is increasing in prevalence.
Gladwin, Mark T. +2 more
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The response of tumour vasculature to angiotensin II revealed by its systemic and local administration to 'tissue-isolated' tumours [PDF]
A tissue-isolated preparation of the P22 rat carcinosarcoma was used to investigate the tumour vascular response to angiotensin II (ATII). In particular, the relative importance of systemic and local tumour factors was assessed by comparing tumour ...
Tozer, G.M., Shaffi, K.M.
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Carotid baroreceptor reflexes in humans during orthostatic stress [PDF]
Orthostatic stress, including standing, head-up tilting and lower body suction, results in increases in peripheral vascular resistance but little or no change in mean arterial pressure.
Cooper, V.L., Hainsworth, R.
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Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms [PDF]
Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes.
Guzik, Tomasz J. +2 more
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