Results 31 to 40 of about 3,425,425 (249)

Evaluation of resistive index of orbital vessels using color doppler imaging in patients with type 2 diabetes mellitus

Journal of Medical Ultrasound, 2021
Background: Resistive index (RI), derived from color Doppler imaging (CDI), is a marker of vascular resistance used widely in varied clinical settings.
Vikrant Kanagaraju, K Divya, M Raajaganesh, B Devanand   +3 more
doaj   +1 more source

Antimicrobial resistance surveillance in Europe 2013: Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net) [PDF]

, 2014
Portugal - EARS-Net Management Team & National representatives of EARS-Net (Manuela Caniça, José Artur Paiva, Vera Manageiro, Eugénia Ferreira)The results presented in this report are based on antimicrobial resistance data from invasive isolates reported
European Antimicrobial Resistance Surveillance Network (EARS-Net)
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Effect of propofol on cerebral blood flow in patients with severe traumatic brain injury undergoing decompression craniectomy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Objective To analyze the effect of propofol on cerebral blood flow (CBF) in patients with severe traumatic brain injury (sTBI). Methods A total of 60 patients of sTBI undergoing unilateral decompression craniectomy in the Department of Neurosurgery from ...
Shao⁃bo REN, Li⁃hong LI
doaj  

Dynamic Arterial Elastance Is Associated With the Vascular Waterfall in Patients Treated With Norepinephrine: An Observational Study

Frontiers in Physiology, 2021
Introduction: It has been suggested that dynamic arterial elastance (Eadyn) can predict decreases in arterial pressure in response to changing norepinephrine levels.
Stéphane Bar, Maxime Nguyen, Maxime Nguyen, Osama Abou-Arab, Hervé Dupont, Belaid Bouhemad, Pierre-Grégoire Guinot, Pierre-Grégoire Guinot   +7 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Analysis of the mechanisms of resistance to Epidermal growth factor receptor inhibitors and development of multiple targeted strategies [PDF]

, 2008
Background. Primary and acquired resistance to selective Epidermal growth factor receptor (EGFR) inhibitors remains the most significant obstacle to the success of these targeted agents in cancer therapy.
Rosa, Roberta
core   +1 more source