Effect Of Mirthful Laughter On Vascular Function [PDF]
, 2010 In contrast to the well-established scientific evidence linking negative emotional states (e.g., depression, anxiety, or anger) to increased risk for cardiovascular disease, much less is known about the association between positive emotional states (e.g.,
Sugawara, Jun +2 more
core +1 more source
Saxagliptin Prevents Increased Coronary Vascular Stiffness in Aortic-Banded Mini Swine
HYPERTENSION, 2018 Increased peripheral conduit artery stiffness has been shown in patients with heart failure (HF) with preserved ejection fraction. However, it is unknown whether this phenomenon extends to the coronary vasculature. HF with preserved ejection fraction may
Bradley S. Fleenor +6 more
semanticscholar +1 more source
Angiogenic and angiostatic factors in renal scleroderma-associated vasculopathy [PDF]
, 2017 BACKGROUND: The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-angiogenic factors and angiogenesis inhibitors has been implicated in the progression of peripheral microvascular damage, defective vascular repair and fibrosis ...
Afeltra, Antonella M. Vittoria +7 more
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Dill extract induces elastic fiber neosynthesis and functional improvement in the ascending aorta of aged mice with reversal of age-dependent cardiac hypertrophy and involvement of lysyl oxidase-like-1 [PDF]
, 2020 Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells through the cross-linking of its soluble precursor, tropoelastin.
Boyle, Walter A +7 more
core +3 more sources
Regulation of blood vessel stiffness by focal adhesions of vascular smooth muscle [PDF]
, 2013 Thesis (Ph.D.)--Boston UniversityThe operation of the cardiovascular system is inherently mechanical. Changes in the stiffness of the vascular tree have been implicated in various pathophysiologic states, and increased aortic stiffening with age is an ...
Saphirstein, Robert Jason
core +1 more source
Persistent Vascular Collagen Accumulation Alters Hemodynamic Recovery from Chronic Hypoxia [PDF]
, 2012 Pulmonary arterial hypertension (PAH) is caused by narrowing and stiffening of the pulmonary arteries that increase pulmonary vascular impedance (PVZ). In particular, small arteries narrow and large arteries stiffen. Large pulmonary artery (PA) stiffness
Chesler, Naomi C. +5 more
core +2 more sources
Sensitivity analysis and uncertainty quantification of 1D models of the pulmonary circulation [PDF]
, 2018 This study combines a one-dimensional (1D) model with micro-CT imaging and hemodynamic data to quantify uncertainty of flow and pressure predictions in the pulmonary arteries in a control and hypoxia induced hypertensive mouse. We use local and global sensitivity and correlation analysis to determine parameters that can be inferred from the model and ...
arxiv +1 more source
Long term effects of mesoglycan on brachial arterial stiffness and MMP-9/TIMP-1 system in patients with metabolic syndrome [PDF]
, 2018 Objectives: The aim of this study was to evaluate the chronic effects of mesoglycan on the vascular remodeling in patients with metabolic syndrome (Mets).
Bosso, Giorgio +4 more
core
Tumor stiffness extends its grip on the metastatic microenvironment [PDF]
, 2017 The increased stiffness of a tumor triggers a multitude of responses that aid cancer cell dissemination. Stiffness-induced expression of CCN1 mediates autocrine signaling in the endothelium to upregulate N-Cadherin levels.
Reid, Steven E., Zanivan, Sara
core +2 more sources
Unraveling the vascular fate of deformable circulating tumor cells via a hierarchical computational model [PDF]
arXiv, 2019 Distant spreading of primary lesions is modulated by the vascular dynamics of circulating tumor cells (CTCs) and their ability to establish metastatic niches. While the mechanisms regulating CTC homing in specific tissues are yet to be elucidated, it is well documented that CTCs possess different size, biological properties and deformability.
arxiv