Results 91 to 100 of about 7,952,783 (243)

Reversal of aging-induced increases in aortic stiffness by targeting cytoskeletal protein-protein interfaces [PDF]

, 2018
BACKGROUND: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole.
Chiu, Joanna, Gao, Yuan, Leavis, Paul, Li, Qian, Mitchell, G. F., Morgan, Kathleen, Nicholson, Christopher, Porter, Tyrone, Saphirstein, Robert, Singh, Kuldeep, Verwoert, Germaine   +10 more
core   +1 more source

A LIGHTning Strike to the Metastatic Niche

Cell Reports, 2020
Tumor-induced vascular alterations in distant organs have been linked to the spreading of cancer. In this issue of Cell Reports, He et al. (2019) show that targeting the cytokine LIGHT to the pulmonary vasculature prevents the establishment of lung ...
Amaia Martinez-Usatorre, Michele De Palma   +1 more
doaj   +1 more source

The ambitious role of anti angiogenesis molecules: Turning a cold tumor into a hot one [PDF]

, 2018
In renal cancer emerging treatment options are becoming available and there is a strong need to combine therapies to reformulate and adjourn clinical practice.
Botticelli, A., Marchetti, P., Nuti, M., Rughetti, A., Zizzari, I. G.   +4 more
core   +1 more source

Targeting the tumour vasculature: exploitation of low oxygenation and sensitivity to NOS inhibition by treatment with a hypoxic cytotoxin. [PDF]

PLoS ONE, 2013
Many cancer research efforts focus on exploiting genetic-level features that may be targeted for therapy. Tissue-level features of the tumour microenvironment also represent useful therapeutic targets.
Jennifer H E Baker, Alastair H Kyle, Kirsten L Bartels, Stephen P Methot, Erin J Flanagan, Andrew Balbirnie, Jordan D Cran, Andrew I Minchinton   +7 more
doaj   +1 more source

Combinatorial vascular targeting in translational medicine [PDF]

PROTEOMICS – Clinical Applications, 2010
AbstractIn the post‐genomic era, the phage display technology surfaces as an alternative approach for large‐scale study of tissue‐specific protein interactions with direct clinical and therapeutic applications. The unbiased identification of molecular complexes expressed on the surface of cells and blood vessels of organs and tissues may eventually ...
Fernanda I, Staquicini, Benjamin J, Moeller, Wadih, Arap, Renata, Pasqualini   +3 more
openaire   +2 more sources

Tumor angiogenic switch determines sustained proliferative malignant transformation in tumorigenesis and overlaps with para-inflammatory phenomena [PDF]

, 2015
Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core  

MiRNA-145 increases therapeutic sensibility to gemcitabine treatment of pancreatic adenocarcinoma cells. [PDF]

, 2016
Pancreatic adenocarcinoma is one of the most leading causes of cancer-related deaths worldwide. Although recent advances provide various treatment options, pancreatic adenocarcinoma has poor prognosis due to its late diagnosis and ineffective therapeutic
Chen, Qiu-Dan, Ge, Xin, Jiang, Bing-Hua, Lin, Yong, Liu, Ling-Zhi, Lu, Yuan, Shi, Zhu-Mei, Wang, Min, Wen, Yiyang   +8 more
core   +2 more sources

Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation. [PDF]

, 2015
Photochemical internalisation (PCI) is a technique for improving cellular delivery of certain bioactive agents which are prone to sequestration within endolysosomes.
Adigbli, Adigbli, Arentsen, Baglo, Berg, Berg, Berg, Berg, Berstad, Bodles-Brakhop, Bostad, Bostad, Bull-Hansen, Castano, Castano, Chong, Dietze, Dietze, Elisabeth Olsen, Fretz, Gaware, Gooding, Gottesman, Hirschberg, Høgset, Jørgensen, Kunz, Lai, Lai, Lakshmanan, Lou, Lu, Lund, Mathews, Mroz, Mroz, Norum, Norum, Norum, Norum, Pasparakis, Peng, Peng, Prasmickaite, Reginato, Rosenblum, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, St Denis, Stratford, Todorova, Vikdal, Wang, Wang, Wang, Weyergang, Weyergang, Woodhams, Xu, Yaghini, Yao, Yip, Zahreddine   +69 more
core   +1 more source

Theoretical impact of insecticide-impregnated school uniforms on dengue incidence in Thai children. [PDF]

, 2013
BACKGROUND: Children carry the main burden of morbidity and mortality caused by dengue. Children spend a considerable amount of their day at school; hence strategies that reduce human-mosquito contact to protect against the day-biting habits of Aedes ...
Amaku, Marcos, Coutinho, Francisco Antonio Bezerra, Kittayapong, Pattamaporn, Massad, Eduardo, Wilder-Smith, Annelies   +4 more
core   +2 more sources

Immune priming and induction of tertiary lymphoid structures in a cord-blood humanized mouse model of gastrointestinal stromal tumor

OncoImmunology
Gastrointestinal stromal tumors (GISTs) harbor diverse immune cell populations but so far immunotherapy in patients has been disappointing. Here, we established cord blood humanized mouse models of localized and disseminated GIST to explore the ...
Bo He, Larissa Dymond, Kira H. Wood, Edward R. Bastow, Jiulia Satiaputra, Ji Li, Anna Johansson-Percival, Juliana Hamzah, M. Priyanthi Kumarasinghe, Mohammed Ballal, Jonathan Foo, Mikael Johansson, Hooi C. Ee, Scott W. White, Louise Winteringham, Ruth Ganss   +15 more
doaj   +1 more source