Results 71 to 80 of about 1,860,910 (290)

Targeting Tumor Vascular CD99 Inhibits Tumor Growth

Frontiers in Immunology, 2019
CD99 (MIC2; single-chain type-1 glycoprotein) is a heavily O-glycosylated transmembrane protein (32 kDa) present on leukocytes and activated endothelium. Expression of CD99 on endothelium is important in lymphocyte diapedesis. CD99 is a diagnostic marker
Elisabeth J. M. Huijbers, Inge M. van der Werf, Lisette D. Faber, Lena D. Sialino, Pia van der Laan, Hanna A. Holland, Anca M. Cimpean, Victor L. J. L. Thijssen, Judy R. van Beijnum, Arjan W. Griffioen   +9 more
doaj   +1 more source

Targeting Vascular Stiffness

Arteriosclerosis, Thrombosis, and Vascular Biology
Artery stiffening, a biomechanical vascular property closely related to but separate from hypertension, is a strong and independent cardiovascular disease risk factor that also predicts end-organ failure. Decreased aortic compliance elevates the mechanical load on the myocardium, increases peripheral pulse pressure which damages high-flow organs ...
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems

Asian Journal of Pharmaceutical Sciences, 2019
Vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) are two prominent antiangiogenic targets. They are highly expressed on vascular endothelial cells and some tumor cells.
Lu Lu, Hongyuan Chen, Dake Hao, Xinke Zhang, Fengshan Wang   +4 more
doaj   +1 more source

The Vascular System as a Target of Metal Toxicity [PDF]

Toxicological Sciences, 2007
Vascular system function involves complex interactions among the vascular endothelium, smooth muscle, the immune system, and the nervous system. The toxic metals cadmium (Cd), arsenic (As), and lead (Pb) can target the vascular system in a variety of ways, ranging from hemorrhagic injury to subtle pathogenic remodeling and metabolic changes.
Walter C, Prozialeck, Joshua R, Edwards, Daniel W, Nebert, James M, Woods, Aaron, Barchowsky, William D, Atchison   +5 more
openaire   +2 more sources

Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk [PDF]

, 2012
We have previously shown that injury-induced neointima formation was rescued by adenoviral-Nogo-B gene delivery. Integrase-competent lentiviral vectors (ICLV) are efficient at gene delivery to vascular cells but present a risk of insertional mutagenesis.
Sessa, W.C., Chick, H.E., Kane, N.M., Baker, A.H., Thrasher, A.J., Alba, R., Fronza, R., McDonald, R.A., Delles, C., Schmidt, M., Nowrouzi, A.   +10 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Notch signaling pathway in human vascular smooth muscle cell differentiation [PDF]

, 2006
Notch receptor-ligand interactions are a highly conserved mechanism, originally described in developmental studies using Drosophilae, that regulate inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to ...
Scheller, Agnieszka
core   +2 more sources

Role of nutritional indices in predicting outcomes of vascular surgery [PDF]

, 2019
Background: Malnutrition is frequent among vascular surgery patients, given their age, chronic comorbidities, and poor functional status, and it is believed to increase their operative risk.
Rabeh, Wissam, Jabbour, Jana, Abou Ali, Adham N., Al-Shaar, Laila, Avgerinos, Efthymios D., Habib, Robert H.   +5 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source