Results 61 to 70 of about 1,860,910 (290)
International Journal of Radiation Oncology*Biology*Physics, 2002 International Journal of Radiation Oncology, Biology, Physics 54 (2002) 1472-1472.
Department of Radiation Oncology, University of Florida Shands Cancer Center, Gainesville, FLUSA ( host institution ) +1 more
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Targeting NADPH oxidases in vascular pharmacology [PDF]
Vascular Pharmacology, 2012 Oxidative stress is a molecular dysregulation in reactive oxygen species (ROS) metabolism, which plays a key role in the pathogenesis of atherosclerosis, vascular inflammation and endothelial dysfunction. It is characterized by a loss of nitric oxide (NO) bioavailability.
Agata, Schramm +3 more
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, 2001 Introduction Functions of vascular endothelial cells in the body Molecular control of tumour growth‐related angiogenesis Role of growth factors VEGF and FGF‐2 Role of integrins Role of the extracellular matrix Role of subendothelial support cells ...
Grietje Molema +7 more
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Tumor rim cells: From resistance to vascular targeting agents to complete tumor ablation
Tumor Biology, 2017 Current vascular targeting strategies pursue two main goals: anti-angiogenesis agents aim to halt sprouting and the formation of new blood vessels, while vascular disrupting agents along with coaguligands seek to compromise blood circulation in the ...
Khaled Seidi +2 more
doaj +1 more source
Frontiers in Immunology, 2023 Blood vessels are a key target for cancer therapy. Compared with the healthy vasculature, tumor blood vessels are extremely immature, highly permeable, and deficient in pericytes.
Cheng Qian +9 more
doaj +1 more source
Vascular targeting and the inhibition of angiogenesis
Annals of Oncology, 1994 Recent advances in our understanding of the process by which tumours elicit an angiogenic response, and of differences between normal and tumour vasculature, are revealing new strategies for anticancer therapy. The current status of anti-angiogenic therapy, together with approaches to targeting tumour vasculature, is reviewed.
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Combinatorial vascular targeting in translational medicine [PDF]
PROTEOMICS – Clinical Applications, 2010 AbstractIn the post‐genomic era, the phage display technology surfaces as an alternative approach for large‐scale study of tissue‐specific protein interactions with direct clinical and therapeutic applications. The unbiased identification of molecular complexes expressed on the surface of cells and blood vessels of organs and tissues may eventually ...
Fernanda I, Staquicini +3 more
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, 2009 Tumoral gastrin-releasing peptide (GRP) receptors are potential targets for diagnosis and therapy using radiolabeled or cytotoxic GRP analogs. GRP-receptor overexpression has been detected in endocrine-related cancer cells and, more recently, also in the
Fleischmann, Achim +2 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source